Article
Neurosciences
Aurelie Edwards, Kimberly R. Long, Catherine J. Baty, Katherine E. Shipman, Ora A. Weisz
Summary: Recent research shows that filtered albumin is mainly retrieved in proximal tubule through receptor-mediated endocytosis. A mathematical model is developed to predict the rates of albumin uptake and suggests that megalin-mediated uptake predominates under nephrotic conditions. The majority of albumin is reabsorbed in the S1 sub-segment.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Biochemistry & Molecular Biology
Ho-Yin Huang, Ting-Wei Lin, Zi-Xuan Hong, Lee-Moay Lim
Summary: Vitamin D is a hormone that participates in various physiological processes. It has been shown to have renoprotective effects by regulating endothelial function, preserving podocytes, modulating the renin-angiotensin-aldosterone system, and exerting anti-inflammatory effects. Current research suggests that vitamin D may delay the onset of diabetic kidney disease. This review summarizes the findings on the role of vitamin D in diabetic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Henry H. L. Wu, Thomas McDonnell, Rajkumar Chinnadurai
Summary: The number of people with chronic kidney disease (CKD) is increasing due to global population growth. As major factors of kidney disease, aging, diabetes, and cardiovascular disease have also led to the rise in diabetic kidney disease (DKD) patients. Poor clinical outcomes in DKD can be influenced by various factors, including inadequate glycemic control, obesity, metabolic acidosis, anemia, cellular senescence, infection and inflammation, cognitive impairment, reduced physical exercise threshold, and importantly, malnutrition leading to protein-energy wasting, sarcopenia, and frailty. Among the causes of malnutrition in DKD, the deficiencies in vitamin B (B1 (thiamine), B2 (riboflavin), B3 (niacin/nicotinamide), B5 (pantothenic acid), B6 (pyridoxine), B8 (biotin), B9 (folate), and B12 (cobalamin)) and their impact have gained scientific interest in the past decade. There is still ongoing debate on the biochemical intricacies of vitamin B metabolic pathways and how their deficiencies affect the development of CKD, diabetes, and subsequently DKD, and vice versa. This article provides a review of current evidence on the biochemical and physiological properties of vitamin B sub-forms in normal states and how deficiencies and defects in their metabolic pathways may influence CKD/DKD pathophysiology, and vice versa. The aim is to raise awareness of vitamin B deficiency in DKD and the complex physiological associations between vitamin B deficiency, diabetes, and CKD. Further research is needed to address the knowledge gaps in this area.
Review
Medicine, Research & Experimental
Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Ahmed Ismail, Ahmed S. Doghish
Summary: The endocytosis mechanism is a complex system essential for cell signaling and survival. Megalin and its related proteins play important roles in receptor-mediated endocytosis and have significant implications for kidney function and injury.
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Vitamin D may play a significant role in the development of diabetic nephropathy, but its influence on the reversal of existing renal damage remains uncertain. Several hypotheses suggest a link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Monica Ceol, Lisa Gianesello, Hernan Trimarchi, Alberto Migliorini, Giovanna Priante, Claudia M. Radu, Elena Naso, Annalisa Angelini, Lorenzo A. Calo, Franca Anglani, Dorella Del Prete
Summary: This study investigated the role of ClC-5, megalin, and cubilin in parietal epithelial cells and found that the number of hypertrophic parietal epithelial cells was significantly higher in lupus nephritis patients. The presence of these cells in Bowman's capsule may provide a potential resource for responding to protein overload in other glomerulonephritis.
JOURNAL OF NEPHROLOGY
(2023)
Article
Pediatrics
Shahid Nadeem, Vin Tangpricha, Thomas R. Ziegler, James E. Rhodes, Traci Leong, Yijin Xiang, Larry A. Greenbaum
Summary: In children with chronic kidney disease, daily supplementation of 1000 IU of vitamin D-3 is unlikely to achieve or maintain a plasma 25(OH)D level >= 30 ng/mL. However, a daily dose of 4000 IU of vitamin D-3 was effective in achieving or maintaining vitamin D sufficiency in children with CKD stages 3-5.
PEDIATRIC NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Article
Dermatology
Juan Lin, Xinxin Mo, Yejun Yang, Chao Tang, Jia Chen
Summary: This meta-analysis found that diabetic subjects with foot ulcer wounds had significantly lower vitamin D levels and higher prevalence of vitamin D deficiency and severe vitamin D deficiency compared with non-ulcerated diabetic subjects.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Review
Nutrition & Dietetics
Marta Zieminska, Beata Sieklucka, Krystyna Pawlak
Summary: Vitamin K and vitamin D deficiency in chronic kidney disease can lead to impaired bone health and increased risk of fractures. Currently, there is no consensus on the optimal supplementation approach for these vitamins in CKD patients.
Article
Cardiac & Cardiovascular Systems
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer, CRIC Study Investigators
Summary: The study investigated the associations of the vitamin D metabolite ratio (VDMR), 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH](2)D) with cardiovascular disease (CVD) in chronic kidney disease patients. The results showed that lower VDMR and 1,25(OH)(2)D were associated with incident CVD, while only 25(OH)D was associated with left ventricular mass index. However, none of these metabolites were found to be associated with incident CVD in chronic kidney disease after adjustment for relevant factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Ting-An Yang, Jau-Yuan Chen, Chieh-An Lin, Yi-Chuan Chen, Wei Yu, Hsiung Ying Huang, Xue-Jie Xiong, Wen-Cheng Li
Summary: This cross-sectional study in China found that vitamin D deficiency is associated with early-stage chronic kidney disease, especially in males.
NUTRITION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Hyunwoo Kim, Miyeon Kim, Hwa-Young Lee, Ho-Young Park, Hyunjhung Jhun, Soohyun Kim
Summary: Diabetic nephropathy is a significant microvascular complication in diabetic patients, with current treatment options insufficient to prevent its progression. Recent studies suggest DN is an inflammatory disease, with immune cells potentially playing a role in its development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Khurrum Shahzad, Sameen Fatima, Moh'd Mohanad Al-Dabet, Ihsan Gadi, Hamzah Khawaja, Saira Ambreen, Ahmed Elwakiel, Nora Kloeting, Matthias Blueher, Peter P. Nawroth, Peter R. Mertens, Sven Michel, Frank Jaschinski, Richard Klar, Berend Isermann
Summary: The study demonstrates that an ASO-based approach reducing CHOP expression can ameliorate DKD in mice, providing renal protection on top of ACE inhibition. Inhibition of CHOP not only improves glomerular damage, but also tubular damage. ASO therapies are a potential new approach to target maladaptive ER stress signaling and improve DKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Yusuke Yata, Michihiro Hosojima, Hideyuki Kabasawa, Tomomi Ishikawa, Ryohei Kaseda, Noriaki Iino, Yoshiki Suzuki, Akihiko Saito, Ichiei Narita
Article
Urology & Nephrology
Yoshihisa Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto, Tomomichi Iida, Shankhajit De, Hideyuki Kabasawa, Reika Kaneko, Hiroyuki Aoki, Yoshinari Tanabe, Hiroshi Kagamu, Ichiei Narita, Toshiaki Kikuchi, Akihiko Saito
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Multidisciplinary Sciences
Michihiro Hosojima, Hisaki Shimada, Yoshitsugu Obi, Shoji Kuwahara, Ryohei Kaseda, Hideyuki Kabasawa, Hazuki Kondo, Mikio Fujii, Reiko Watanabe, Yoshiki Suzuki, Motoni Kadowaki, Shigeru Miyazaki, Akihiko Saito
SCIENTIFIC REPORTS
(2017)
Article
Cardiac & Cardiovascular Systems
R. Kaseda, Y. Tsuchida, J. L. Gamboa, J. Zhong, L. Zhang, H. Yang, A. Dikalova, A. Bian, S. Davies, A. F. Fogo, M. F. Linton, N. J. Brown, T. A. Ikizler, V. Kon
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2018)
Article
Urology & Nephrology
Ryohei Kaseda, Yohei Tsuchida, Hai-Chun Yang, Patricia G. Yancey, Jianyong Zhong, Huan Tao, Aihua Bian, Agnes B. Fogo, Mac Rae F. Linton, Sergio Fazio, Talat Alp Ikizler, Valentina Kon
Article
Urology & Nephrology
Koji Toba, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Toshiko Murayama, Keiko Yamamoto-Kabasawa, Ryohei Kaseda, Eri Wada, Reiko Watanabe, Naohito Tanabe, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito
Article
Oncology
Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu, Akihiko Saito
Article
Nutrition & Dietetics
Yuki Higuchi, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Sawako Goto, Koji Toba, Ryohei Kaseda, Takahiro Tanaka, Nobutaka Kitamura, Hayato Takihara, Shujiro Okuda, Masayuki Taniguchi, Hitoshi Arao, Ichiei Narita, Akihiko Saito
Article
Endocrinology & Metabolism
Tomomi Ishikawa-Tanaka, Michihiro Hosojima, Hideyuki Kabasawa, Ryohei Kaseda, Ryota Yasukawa, Yusuke Yata, Shoji Kuwahara, Emiko Kono, Takuma Takata, Noriaki Iino, Takahiro Tanaka, Nobutaka Kitamura, Yoshiki Suzuki, Akihiko Saito, Ichiei Narita
Letter
Pharmacology & Pharmacy
Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Satoru Mitsuboshi, Ryohei Kaseda, Ichiei Narita
Summary: This study suggests that steroid use may reduce the risk of proton pump inhibitor-induced nephropathy. Factors such as the presence of chronic kidney disease, comorbidities related to nephropathy, male sex, and age >= 80 years are associated with kidney injury.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ryohei Kaseda, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Yuki Higuchi, Valentina Kon, Ichiei Narita, Akihiko Saito
Summary: The study found that a rice endosperm protein (REP)-based diet has better efficacy in reducing renal injury-driven atherosclerosis compared to a casein-based diet, potentially due to the anti-inflammatory effects of HDL.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Urology & Nephrology
Yusuke Nakagawa, Ryohei Kaseda, Yuya Suzuki, Hirofumi Watanabe, Tadashi Otsuka, Suguru Yamamoto, Yoshikatsu Kaneko, Shin Goto, Yasuhiko Terada, Tomoyuki Haishi, Susumu Sasaki, Ichiei Narita
Summary: This study investigates the changes in sodium concentrations in mice under normal conditions and in a diabetic mouse model using sodium magnetic resonance imaging. The results show that sodium concentrations in the kidney are decreased in both normal and diabetic conditions. This imaging technique can be useful for evaluating functional changes in diabetic kidney disease.
Article
Urology & Nephrology
Tadashi Otsuka, Yoshikatsu Kaneko, Yuya Sato, Ryohei Kaseda, Ryuji Aoyagi, Suguru Yamamoto, Shin Goto, Ichiei Narita
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)
Article
Endocrinology & Metabolism
Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, Tomomi Ishikawa, Ryohei Kaseda, Piyali Sarkar, Yusuke Yoshioka, Hideyuki Kabasawa, Tomomichi Iida, Sawako Goto, Koji Toba, Yuki Higuchi, Yoshiki Suzuki, Masanori Hara, Hiroyuki Kurosawa, Ichiei Narita, Yoshiaki Hirayama, Takahiro Ochiya, Akihiko Saito