Article
Plant Sciences
Yu Duan, Xiaowen Shang, Guodong Liu, Zhongwei Zou, Xujun Zhu, Yuanchun Ma, Fang Li, Wanping Fang
Summary: The study found that there were significant changes in the metabolic of secondary metabolites in tea plants when intercropped with soybean, especially during the profuse flowering stage of soybean. Through the intercropping system, tea plants showed higher chlorophyll photosynthetic parameters and photosynthetic activity. These results provide a basis for reducing the application of nitrogen fertilizer and improving the ecosystem in tea plantations.
Article
Environmental Sciences
Zixuan Wang, Hui Shi, Ling Peng, Yue Zhou, Ying Wang, Fei Jiang
Summary: This study found gender-specific differences in the association between environmental tobacco smoke exposure biomarkers and developmental disorders. Only girls with low cotinine levels and high urinary NNAL levels had higher odds of having developmental disorders, while the effects of boys and NNAL exposure were additive.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Giuliano E. Pereira, Emily M. T. Padhi, Mysore R. Sudarshana, Flavio Bello Fialho, Cristina Medina-Plaza, Raul C. Girardello, Dave Tseng, Robert C. Bruce, Jesse N. Erdmann, Carolyn M. Slupsky, Anita Oberholster
Summary: This study evaluated the impact of grapevine red blotch disease (GRBD) on agronomical parameters of 'Cabernet Sauvignon' vines at harvest using metabolomics approach. The results showed that GRBD influenced degrees Brix, berry weight, primary and secondary metabolites in both skin + pulp/flesh and seeds. The effectiveness of 1D H-1 NMR and RP-HPLC in quantifying impacted metabolites was compared and the most affected metabolites in each tissue were identified.
Article
Plant Sciences
Cai Qin, Tingting Du, Ruiyu Zhang, Qiujie Wang, Yang Liu, Tianyi Wang, Hongyan Cao, Qian Bai, Yu Zhang, Shuchai Su
Summary: This study analyzed the transcriptomes, metabolomes, and phytohormones of male and female chestnut flowers during spring and late summer, revealing the developmental differences between the first and secondary flowering stages. EREBP-like and HSP20 were found to mainly affect the development of secondary female and male flowers, respectively. Additionally, genes and metabolites positively correlated with secondary flower formation were identified, while abscisic and salicylic acids were negatively correlated. This study provides a theoretical basis for the reproductive development mechanism of chestnuts and has important practical implications for improving chestnut yield and quality.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Lior Gur, Yigal Cohen, Omer Frenkel, Ron Schweitzer, Meir Shlisel, Moshe Reuveni
Summary: The foliar application of potassium phosphate fertilizer and micronutrients can effectively reduce the incidence and severity of powdery mildew on grape leaves and berries. These fertilizers are as effective as fungicides and can increase the production of anti-fungal and antioxidant metabolites, providing further control of the disease and improving wine quality.
Article
Food Science & Technology
Narae Han, Inhwan Kim, Jongkee Kim, Jihyun Lee
Summary: The study investigated the distribution and changes in primary and secondary metabolite profiles of Baemoochae, an inter-generic hybrid of Chinese cabbage and radish, during different developmental stages. Results showed that mature Baemoochae roots could serve as a rich source of glucosinolates with potential health-promoting effects, indicating significant differences in metabolite composition between tissues and plant maturity.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Lisa Fagerli Lunde, Rannveig Jacobsen, Havard Kauserud, Lynne Boddy, Line Nybakken, Anne Sverdrup-Thygeson, Tone Birkemoe
Summary: During the decomposition of organic matter, the assembly history, resource quality, and the arrival of primary and secondary colonizers can affect the composition of fungal communities and the rate of wood decay. The study found that the gradient of fungal community composition is related to resource quality and that the initial fungal community explains the variation in community composition. Additionally, the exclusion of invertebrates has a lasting impact on fungal communities.
Article
Biotechnology & Applied Microbiology
Xuepeng Fu, Song Liu, Jiarong Ru, Biyao Tang, Yujia Zhai, Zhigang Wang, Lichun Wang
Summary: The bacterial isolate Streptomyces sp. FXP04 obtained from the rhizosphere soil of potato plants showed significant inhibition against the mycelial growth of Phytophthora infestans, the pathogen causing potato late blight. The genome sequencing of Streptomyces sp. FXP04 identified 15 gene clusters responsible for the biosynthesis of secondary metabolites, including the antimicrobial compound Piericidin A. Metabolomic analysis confirmed the presence of Piericidin A, which was shown to inhibit the growth of P. infestans. These findings suggest that Streptomyces sp. FXP04 could be a potential biocontrol agent for potato late blight, with Piericidin A as the key antimicrobial secondary metabolite.
BIOLOGICAL CONTROL
(2022)
Review
Horticulture
XIAo-XIA Pan, YoU-YoNG Zhu, Ming-zhi Yang
Summary: This review summarizes recent data on the stress of grape berry development, with special emphasis on secondary metabolism and its response to stresses. A full understanding of how grape berry metabolism responds to different stresses is important for improving the quality of grapes and resultant wine.
Article
Agronomy
Micaela alvarez, Isadora Agostini, Sofia Silva, Rosangela Dallemole-Giaretta, Michael Sulyok, Ana Sampaio, Paula Rodrigues
Summary: This study aimed to investigate the effect of a new biocontrol agent (BCA) on the growth and secondary metabolite production of the pathogen Gnomoniopsis smithogilvyi (Gs) in chestnut. The biocontrol agent was compared with a chemical fungicide and a commercial biofungicide. All agents showed reduction in the growth of Gs, with the biocontrol agent at an intermediate concentration being the most effective. Metabolite analysis revealed the production of two mycotoxins by Gs, and the chemical fungicide stimulated the production of one of these mycotoxins. These findings highlight the potential health risks associated with Gs and the need to use effective concentrations of biocontrol agents or combine them with other strategies to mitigate the hazard.
Article
Agriculture, Multidisciplinary
Wang Hui, Zhang Wei, Simone Bregaglio, Shuyi Yu, Xinghong Li, Yonghua Li, Chunhao Liang, Jiye Yan
Summary: This study proposes a grape downy mildew model to optimize plant disease management in northern Chinese grapevine areas. The study finds that northern China is becoming more suitable for grape downy mildew infections, along with warmer temperatures and more frequent rainfall.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Boruta, Anna Scigaczewska, Agnieszka Ruda, Marcin Bizukojc
Summary: Bioreactor cocultures involving Penicillium rubens and Streptomyces rimosus were investigated to analyze secondary metabolite production, morphological development, dissolved oxygen levels, and carbon substrate utilization. Three inoculation approaches were tested, and it was found that the delayed inoculation of S. rimosus did not prevent its growth and biosynthetic activity. This method resulted in increased levels of certain metabolites compared to monocultures. This study demonstrates the usefulness of the delayed inoculation approach in understanding the metabolic landscape and altering secondary metabolite levels.
Article
Multidisciplinary Sciences
Laura Pazzagli, David Liang, Morten Andersen, Marie Linder, Abdul Rauf Khan, Maurizio Sessa
Summary: The assessment of the duration of pharmacological prescriptions is crucial in pharmacoepidemiologic studies, and the Sessa Empirical Estimator (SEE) is a promising new method for computing prescription duration. The SEE showed good accuracy and sensitivity when compared to simulated and real-world data and outperformed the Researcher-Defined Duration (RDD) method.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Mechanical
Bin Chen, Rongrong Guo, Shuyue Yu, Yang Yu
Summary: This paper proposes a novel active noise control method based on signal decomposition and simultaneous perturbation, which effectively controls non-stationary reference noise under a time-variant secondary path by decomposing the reference noise into a series of intrinsic mode functions and applying simultaneous perturbation for control. Experiments demonstrate that the proposed method outperforms commonly used algorithms.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2021)
Article
Engineering, Electrical & Electronic
Mohammad S. Golsorkhi, David J. Hill, Mehdi Baharizadeh
Summary: The paper proposes a new hierarchical control scheme for accurate load sharing and power quality enhancement in networked microgrids with unbalanced load currents. The scheme involves coordination of local DER controllers, MG control units, and Networked MG control center to achieve efficient sharing of power and maintenance of power quality.
IEEE TRANSACTIONS ON SMART GRID
(2021)
Article
Gastroenterology & Hepatology
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Summary: Intestinal PPAR alpha signaling modulates fatty acid uptake through regulating FABP1 expression, contributing to NASH progression. Targeting this pathway could be a potential therapeutic strategy for NASH treatment.
Article
Chemistry, Analytical
Huan-Huan Zhu, Yuan Li, Li-Xia Wu, Ke-Sheng Wang, Yue Zhang, Qiang-Yuan Fan, Zun-Zhen Ming, Wei-Qin Chen, Wei-Wei Liu
Summary: Loop-mediated isothermal amplification (LAMP) is a promising diagnostic tool for genetic amplification, known for its speed, simplicity, efficiency, and sensitivity. This research introduces an internal heating method for LAMP using magnetic nanoparticles (MNPs) called nano-LAMP, which can detect low concentrations of HPV and has been validated in clinical samples.
Article
Business
Hongdan Zhao, Yuanhua Chen, Weiwei Liu
Summary: This study constructs a theoretical model based on the self-determination theory to explore how socially responsible human resource management (SRHRM) influences employee moral voice through autonomous motivation and considers the moderating role of person-organization value fit. With a two-stage research method and analysis of 260 valid data, the study found that SRHRM promotes employee moral voice and this positive linkage is mediated by autonomous motivation. Furthermore, the findings reveal that person-organization fit moderates the indirect influences of SRHRM on moral voice via autonomous motivation.
JOURNAL OF BUSINESS ETHICS
(2023)
Article
Oncology
Dapeng Li, Changyu Yao, Zhao Ding, Ping Liu, Xue Chen, Weiwei Liu, Fangzheng Yi, Chuanya Jiang, Hongwu Li, Yehai Liu, Jing Wu
Summary: The study reveals that PES1 expression is associated with prognosis and tumour growth in head and neck squamous cell carcinoma. It also plays a role in drug resistance and may serve as a potential cancer marker and therapeutic target for HNSCC.
Article
Infectious Diseases
Min Jiang, Weiqin Chen, Yong Chen, Jia Chen, Yue Zhang, Hongmei Yin, Yi Li, Weiwei Liu
Summary: The study evaluated the analytical performance of three COVID-19 detection assays: Coyote assay, BioGerm assay, and DaAn assay. The results showed high consistency among these assays, providing a reference for COVID-19 diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Gastroenterology & Hepatology
Shuai Yang, Ling Qian, Zhixuan Li, Ye Li, Jian Bai, Bo Zheng, Kun Chen, Xinyao Qiu, Guoxiang Cai, Shan Wang, Haiyan Huang, Jianmin Wu, Yanjing Zhu, Qianwen Zhangyang, Lanyun Feng, Tong Wu, Rui Wu, Airong Yang, Kaiting Wang, Ruiru Wang, Yani Zhang, Yan Zhao, Wenwen Wang, Jinxia Bao, Siyun Shen, Ji Hu, Xuan Wu, Tao Zhou, Zhiqiang Meng, Weiwei Liu, Hongyang Wang, Peng Wang, Lei Chen
Summary: This study characterized the immune microenvironment subtypes of liver metastases and identified potential mechanisms using mass cytometry, transcriptomic and whole-exome sequencing. Five distinct immune subtypes were identified, and patients with terminally exhausted or rare T-cell-inflamed characteristics showed worse prognosis. Increased intratumor heterogeneity, somatic mutations in TP53, KRAS, APC, and PIK3CA, and hyperactivated hypoxia signaling contributed to the formation of these aggressive subtypes. SLC2A1 was found to promote immune suppression and escape in liver metastatic lesions through interaction with Spp1 thorn macrophages and regulatory T cells, and also played a role in primary colorectal cancer.
Article
Engineering, Biomedical
Meiyu Bao, Keyi Wang, Jingqiang Li, Yueying Li, Huanhuan Zhu, Meiling Lu, Yue Zhang, Qiangyuan Fan, Lin Han, Kesheng Wang, Dongyan Wang, Yan Gao, Bo Peng, Zunzhen Ming, Weiwei Liu
Summary: A nanomedicine was designed and fabricated to treat inflammatory bowel disease by modulating mucosal immune homeostasis and optimizing intestinal microorganisms. The nanomedicine exhibited anti-inflammatory function, inflammatory targeting property, and positive regulation of gut microflora. This study provides a new approach for the clinical treatment of colitis.
ACTA BIOMATERIALIA
(2023)
Article
Genetics & Heredity
Liyan Deng, Wangchang Li, Weiwei Liu, Yanwen Liu, Bingkun Xie, Martien A. M. Groenen, Ole Madsen, Xiaogan Yang, Zhonglin Tang
Summary: This study compared the metabolic and transcriptomic profiles of Duroc and Luchuan pigs' longissimus dorsi muscle. The results showed that Luchuan pigs had lower levels of certain amino acids, organic acids and nucleic acids, bile acids and hormones, while higher levels of glycerophospholipids, fatty acids, oxidized lipids, alcohols, and amines. Transcriptome analysis also revealed upregulation of genes related to key energy metabolic pathways in Luchuan muscle, while downregulation of genes related to fatty acid oxidation and cholesterol synthesis.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Bruce G. Taylor, Elizabeth A. Mumford, Alejandra M. Kaplan, Weiwei Liu
Summary: There is a lack of research on COVID-19 vaccine hesitancy among law enforcement officers, which hinders the development of health messaging for both officers and the communities they serve. This study aimed to address this gap by conducting the first nationally representative survey of officers on COVID-19 vaccine hesitancy. The findings revealed that 40% of officers were hesitant towards the COVID-19 vaccine, with factors such as education, age, experience, health checkups, and agency policies influencing their hesitancy.
Article
Gastroenterology & Hepatology
Quanri Zhang, Weiwei Liu, Katarzyna Bulek, Han Wang, Megan R. McMullen, Xiaoqin Wu, Nicole Welch, Renliang Zhang, Jaividhya Dasarathy, Srinivasan Dasarathy, Laura E. Nagy, Xiaoxia Li
Summary: This study investigated the association between the endogenous Mincle ligand beta-glucosylceramide (beta-GluCer) and the severity of alcohol-associated liver disease (ALD). The results showed that beta-GluCer concentrations were increased in the serum of patients with severe AH and correlated with disease severity. The study also revealed that beta-GluCer activates Mincle-dependent gasdermin D-mediated formation and release of IL-1 beta-containing extracellular vesicles (sEVs), which contribute to hepatocyte cell death and the pathogenesis of ALD.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hailong Shen, Fangzheng Yi, Zhao Ding, Weiwei Liu, Ping Liu, Zixi Wang, Shixian Liu, Yehai Liu, Dapeng Li
Summary: This study investigated the expression and role of SEC11A in head and neck squamous cell carcinoma (HNSCC). The results showed that SEC11A expression was significantly elevated in HNSCC tissues compared to adjacent normal tissues. Functional assays demonstrated that SEC11A knockdown reduced cell proliferation, migration, and invasion in vitro, and inhibited tumor growth in vivo. These findings suggest that SEC11A plays a crucial role in HNSCC proliferation and progression, and may serve as a potential therapeutic target.
Correction
Multidisciplinary Sciences
Hailong Shen, Fangzheng Yi, Zhao Ding, Weiwei Liu, Ping Liu, Zixi Wang, Shixian Liu, Yehai Liu, Dapeng Li
Article
Medicine, Research & Experimental
Jianxin Xiao, Xing Chen, Weiwei Liu, Wen Qian, Katarzyna Bulek, Lingzi Hong, William Miller-Little, Xiaoxia Li, Caini Liu
Summary: TRAF4 plays an important role in IL-33-mediated type 2 pulmonary inflammation by regulating the proliferation of ST2+ mTh2 cells and influencing the development of lung inflammation.
Article
Oncology
Ke Li, Xuan Wu, Yuan Li, Ting-Ting Hu, Weifeng Wang, Frank J. Gonzalez, Weiwei Liu
Summary: This study finds that AKAP12 is associated with stem cell characteristics in colorectal cancer stem cells and regulates the development of colorectal cancer. By regulating the expression of AKAP12 gene, colony formation, sphere formation, and stem cell marker expression in colorectal cancer cells can be reduced. AKAP12 may affect the expression of stemness markers through the AKAP12/PKC/STAT3 signaling pathway, making it an important therapeutic target for blocking the development of colorectal cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Microbiology
Wei-Wei Liu, Piaopiao Pan, Ning-Yi Zhou
Summary: This study reveals the potential of ANME in metabolizing aromatic compounds in cold seep environments through CoA activation of the benzene ring. The presence of PCL and BCL genes in ANME genomes and cold seep environments suggests the capability of heterotrophic metabolism of aromatic compounds by ANME.
MICROBIOLOGY SPECTRUM
(2023)
