Journal
THEORETICAL CHEMISTRY ACCOUNTS
Volume 125, Issue 3-6, Pages 329-334Publisher
SPRINGER
DOI: 10.1007/s00214-009-0698-6
Keywords
Raman spectroscopy; Breast cancer; Principal component analysis; Biochemical analysis; Linear discriminant analysis; Quadratic correlation analysis
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Funding
- FAPESP
- CNPq [0114384-8, 301362/2006-8]
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The aim of this study was to evaluate the vibrational modes of malignant and benign breast tissues with the following diagnosis: fibroadenoma, invasive ductal carcinoma, ductal carcinoma in situ, and fibrocystic condition. Quadratic discriminate analysis, a multivariate statistical method of analysis, showed 98.5% separation between normal and altered tissue. Significant changes were observed at the lower Raman shift for altered tissue. For a better understanding of the spectral differences, a biochemical interpretation was also performed in terms of the reduction and oxidation processes in the cell environment which could be associated with an inflammatory reaction.
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