Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products

A mechanism-Based Approach for Absorption Modeling: The Gastro-Intestinal Transit Time (GITT) Model

(2012) Emilie Hénin et al.   AAPS Journal

Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-Autonomous Hepatocyte Components

(2011) S. Sheikh-Bahaei et al.   DRUG METABOLISM AND DISPOSITION

A Semi-mechanistic Modeling Strategy for Characterization of Regional Absorption Properties and Prospective Prediction of Plasma Concentrations Following Administration of New Modified Release Formulations

(2011) Martin Bergstrand et al.   PHARMACEUTICAL RESEARCH

Relational grounding facilitates development of scientifically useful multiscale models

(2011) C Anthony Hunt et al.   Theoretical Biology and Medical Modelling

MDCK Cystogenesis Driven by Cell Stabilization within Computational Analogues

(2011) Jesse A. Engelberg et al.   PLoS Computational Biology

Oral drug delivery in personalized medicine: Unmet needs and novel approaches

(2010) Klaus Wening et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Identifying the Rules of Engagement Enabling Leukocyte Rolling, Activation, and Adhesion

(2010) Jonathan Tang et al.   PLoS Computational Biology

Evaluation of Bioequivalence for Highly Variable Drugs with Scaled Average Bioequivalence

(2009) Laszlo Tothfalusi et al.   CLINICAL PHARMACOKINETICS

At the Biological Modeling and Simulation Frontier

(2009) C. Anthony Hunt et al.   PHARMACEUTICAL RESEARCH

Discovering Plausible Mechanistic Details of Hepatic Drug Interactions

(2008) T. N. Lam et al.   DRUG METABOLISM AND DISPOSITION

Dichotomies between computational and mathematical models

(2008) C Anthony Hunt et al.   NATURE BIOTECHNOLOGY