4.0 Article

Copper-catalyzed asymmetric propargylic amination of propargylic acetates with amines using BICMAP

Journal

TETRAHEDRON-ASYMMETRY
Volume 24, Issue 23, Pages 1520-1523

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2013.10.007

Keywords

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [WAKATE B-22750082]
  2. COE Start-up Program in the Chiba University
  3. Grants-in-Aid for Scientific Research [24655025, 25288017] Funding Source: KAKEN

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The copper-catalyzed asymmetric propargylic amination of propargylic acetates 1 with amines 2 using BICMAP as a chiral ligand gave the desired products 3 in good yields and with moderate to high enantioselectivities (up to 90% ee). (C) 2013 Elsevier Ltd. All rights reserved.

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