4.0 Article

tert-Butanesulfinylthioether ligands: synthesis and application in palladium-catalyzed asymmetric allylic alkylation

Journal

TETRAHEDRON-ASYMMETRY
Volume 22, Issue 5, Pages 575-579

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2011.02.031

Keywords

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Funding

  1. NSFC [20872139, 21072186]
  2. West Light Foundation of CAS
  3. National Basic Research Program of China (973 Program) [2010CB833300]
  4. Chengdu Institute of Biology, CAS [Y0B1051100]

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A class of novel chiral SO-S-type bidentate ligands based on the tert-butylsulfinyl moiety as the sole chiral source were designed and synthesized through a simple and efficient pathway. These ligands are effective catalyst precursors for the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate and moderate to good stereoselectivities (up to 84% ee) were obtained. (C) 2011 Elsevier Ltd. All rights reserved.

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