4.0 Article

A new chiral phosphine oxide ligand for enantioselective 1,3-dipolar cycloaddition reactions of azomethine ylides

Journal

TETRAHEDRON-ASYMMETRY
Volume 21, Issue 20, Pages 2535-2541

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2010.10.002

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Funding

  1. Scientific and Technical Research Council of Turkey (TUBITAK ) [TBAG-U/173]
  2. National Science Foundation [CHE-553313]
  3. Middle East Technical University

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A new set of phosphorus-containing chiral ligands has been synthesized and used with silver(I) for the catalytic asymmetric 1 3-dipolar cycloaddition reaction of azomethine ylides One of these ligands (POFAM6) was found to produce an effective catalyst for the asymmetric 1 3 dipolar cycloaddition reaction of azomethine ylides with electron deficient dipolarophiles to form pyrrolidines in up to 97% yield and 89% (C) 2010 Elsevier Ltd All rights reserved

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