Review
Microbiology
Jingxuan Zhou, Yi Cai, Ying Liu, Haoyue An, Kaihong Deng, Muhammad Awais Ashraf, Lili Zou, Jun Wang
Summary: The development of new antimicrobials is urgent and difficult due to the emergence of antibiotic resistance in bacteria. The bacterial cell wall is a high-priority target for antibiotic screening, and extensively studied targets in the cell wall have been reviewed. Recent advances in peptidoglycan, lipopolysaccharide, teichoic acid, and lipoprotein have also been discussed. New methods such as macromolecular labeling and structure-based drug design hold promise for screening ideal antibiotics.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Xia Wu, Jing Han, Guoli Gong, Mattheos A. G. Koffas, Jian Zha
Summary: Wall teichoic acids (WTAs) are charged glycopolymers containing phosphodiester-linked polyol units, serving important physiological functions in Gram-positive cell division, gene transfer, surface adhesion, drug resistance, and biofilm formation. WTAs play critical roles in antimicrobial resistance, virulence, interaction with bacteriolytic enzymes, and regulation of cell metabolism, with wide applications in antibacterial drug discovery, vaccine development, pathogen detection, and microbial production. Major challenges and potential future directions in exploring WTA physiology and applications are also discussed.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Tapasi Manna, Anup Kumar Misra
Summary: In this study, a concise synthetic strategy was developed for the synthesis of the sialic acid-containing tetrasaccharide repeating unit of Escherichia coli O131 strain's cell wall O-antigen using regio- and stereoselective glycosylation of judiciously protected sialic acid thioglycoside derivatives.
CARBOHYDRATE RESEARCH
(2022)
Article
Food Science & Technology
Wanwan Hou, Shimo Kang, Jiang Chang, Xiaorong Tian, Chunlei Shi
Summary: The study demonstrated that by inducing GlpQ to degrade WTA, LBA effectively inhibits the biofilm formation of Staphylococcus aureus, reducing its adhesive ability.
Article
Microbiology
Takura Wakinaka, Minenosuke Matsutani, Jun Watanabe, Yoshinobu Mogi, Masafumi Tokuoka, Akihiro Ohnishi
Summary: This study identified the ribitol-containing wall teichoic acid as a crucial receptor for bacteriophage infection in Tetragenococcus halophilus. The mechanisms of host-phage interactions were investigated through gene mutation analysis.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Alexander S. Shashkov, Elena M. Tul'skaya, Natalia Potekhina, Andrey S. Dmitrenok, Sofia N. Senchenkova, Vlad A. Zaychikov, Lubov Dorofeeva, Lyudmila Evtushenko
Summary: The passage discusses the presence of two glycopolymers in the cell wall of Rathayibacter sp. VKM Ac-2759, detailing the structure of each polymer and emphasizing the significance of these findings in taxonomic research and understanding the mechanisms of plant colonization and infection by bacteria of the Rathayibacter genus.
BIOCHEMISTRY-MOSCOW
(2021)
Review
Infectious Diseases
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Kyung-Jin Cho, Young-Mog Kim
Summary: Wall teichoic acid and lipoteichoic acid are important structural components of Gram-positive bacteria, affecting their physiology, virulence, and pathogenicity. Targeting these components could be a potential approach to reduce bacterial infection, and there have been numerous studies in this field.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Plant Sciences
Thanh-Hau Huynh, Jayho Lee, Dong Hyun Moon, Thanh Quang Nguyen, Sangkeun Son, Sunghoon Hwang, Young Eun Du, Jinsheng Cui, Jae-Hyuk Jang, Sang-Jip Nam, Jongheon Shin, Jichan Jang, Sang Kook Lee, Ki-Bong Oh, Dong-Chan Oh
Summary: Single-strain cultivation of a mountain soil-derived Streptomyces sp. GA02 and its coculture with Pandoraea sp. GA02N produced two aromatic products, gwanakosides A and B, which displayed inhibitory and antiproliferative activities against pathogenic bacteria and human cancer cell lines, respectively. The chemical structures, absolute configurations, and bioactivities of these compounds were elucidated through spectroscopic analysis, quantum mechanics-based methods, and chemical derivatization followed by biological assays.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Alexander S. Shashkov, Natalia Potekhina, Elena M. Tul'skaya, Andrey S. Dmitrenok, Sof'ya N. Senchenkova, Lubov Dorofeeva, Vlad A. Zaychikov, Lyudmila Evtushenko
Summary: The cell wall of Rathayibacter caricis VKM Ac-1799(T) was found to contain both neutral and acidic glycopolymers, specifically D-rhamnopyranan and a teichuronic acid with branched repeating units. The structures of these polymers were determined by chemical and NMR spectroscopic methods.
CARBOHYDRATE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Barbara Bellich, Nika Janez, Meta Sternisa, Anja Klancnik, Neil Ravenscroft, Roberto Rizzo, Jerica Sabotic, Paola Cescutti
Summary: The non-pathogenic bacterium Listeria innocua is proposed as a surrogate organism for studying antimicrobial strategies against the foodborne pathogen Listeria monocytogenes. In this study, the structure of wall teichoic acids (WTAs) in L. innocua strain ZM39 was determined and found to be different from other known Listeria WTAs. Additionally, the genome of L. innocua ZM39 was sequenced and putative WTA synthesis genes were identified.
CARBOHYDRATE RESEARCH
(2022)
Article
Genetics & Heredity
Sara M. Tamminga, Simon L. Voelpel, Kim Schipper, Thilo Stehle, Yvonne Pannekoek, Nina M. van Sorge
Summary: This study analyzed the presence and genetic variation of three WTA glycosyltransferases in the Staphylococcus aureus population. The researchers found that tarS was almost universally present in the isolates, while the co-presence of tarM and tarP were associated with specific S. aureus clonal complexes. Variations in WTA glycosylation, caused by amino acid substitutions or premature stop codons in key enzymatic residues, were found to severely affect immune recognition of the bacteria.
MICROBIAL GENOMICS
(2022)
Article
Chemistry, Medicinal
Gil Soo Kim, Jun-Pil Jang, Tae Hoon Oh, Mincheol Kwon, Byeongsan Lee, Jung-Sook Lee, Sung-Kyun Ko, Young-Soo Hong, Jong Seog Ahn, Jae-Hyuk Jang
Summary: Two angucyclines, pseudonocardones D and E, were isolated from Streptomyces sp. KCB15JA151, and their planar structure was elucidated through comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on various analytical methods. Compound 1 was predicted to be an ER alpha antagonist through computational target prediction and further tests confirmed its antiestrogenic activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Genetics & Heredity
Sara M. Tamminga, Simon L. Voelpel, Kim Schipper, Thilo Stehle, Yvonne Pannekoek, Nina M. van Sorge
Summary: Staphylococcus aureus is a leading cause of skin and soft tissue infections and systemic infections. Wall teichoic acids (WTAs) are important for S. aureus colonization, gene transfer, and antibiotic resistance. Genetic variation of the three WTA glycosyltransferases affects immune recognition and clearance of S. aureus.
MICROBIAL GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Manyu Zhang, Jinwei Ren, Yuanming Luo, Weidong Xie, Erwei Li
Summary: Six new polyene carboxylic acids named serpentemycins E-J, together with three known analogs, were isolated from the fermentation medium of Streptomyces sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated based on HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds 1-9 against NO production in LPS-activated RAW264.7 cells were evaluated, and compound 9 showed an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 μM.
Article
Chemistry, Organic
Angela A. Salim, Kaumadi Samarasekera, Taizong Wu, Robert J. Capon
Summary: In this study, rare phosphorylated natural products were detected through molecular network analysis of Streptomyces sp. CMB-MW079. Optimal conditions for the production, isolation, and identification of these natural products were established using miniaturized cultivation profiling (MATRIX). Novel compounds, including the polyketide delta-lactone phoslactomycin E and new ester homologues, as well as unprecedented heterocyclic analogues, were successfully synthesized, isolated, and identified. A biogenetic relationship was proposed between these cometabolites and the known lactomycins A-C.
Article
Chemistry, Organic
Samir Ghosh, Sharmeen Nishat, Peter R. Andreana
JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Chemistry, Organic
Pradheep Eradi, Samir Ghosh, Peter R. Andreana
Article
Chemistry, Medicinal
Samir Ghosh, Pallavi Tiwari, Shashi Pandey, Anup Kumar Misra, Vinita Chaturvedi, Anil Gaikwad, Shalini Bhatnagar, Sudhir Sinha
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2008)
Article
Chemistry, Medicinal
Samir Ghosh, Anup Kumar Misra, Gitika Bhatia, M. M. Khan, A. K. Khanna
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2009)
Article
Biochemistry & Molecular Biology
Samir Ghosh, Anup Kumar Misra
JOURNAL OF CARBOHYDRATE CHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Samir Ghosh, Peter R. Andreana
JOURNAL OF CARBOHYDRATE CHEMISTRY
(2014)
Article
Chemistry, Organic
Shashi Pandey, Samir Ghosh, Anup Kumar Misra
SYNTHESIS-STUTTGART
(2009)
Article
Chemistry, Inorganic & Nuclear
Samir Ghosh, Anup Kumar Misra
TETRAHEDRON-ASYMMETRY
(2010)
Article
Chemistry, Inorganic & Nuclear
Samir Ghosh, Anup Kumar Misra
TETRAHEDRON-ASYMMETRY
(2010)
Article
Biochemistry & Molecular Biology
F. Hossain, S. Nishat, S. Ghosh, S. Boga, G. T. Hymel, P. R. Andreana
JOURNAL OF CARBOHYDRATE CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Brendan T. Freitas, Daniil A. Ahiadorme, Rahul S. Bagul, Ian A. Durie, Samir Ghosh, Jarvis Hill, Naomi E. Kramer, Jackelyn Murray, Brady M. O'Boyle, Emmanuel Onobun, Michael G. Pirrone, Justin D. Shepard, Suzanne Enos, Yagya P. Subedi, Kapil Upadhyaya, Ralph A. Tripp, Brian S. Cummings, David Crich, Scott D. Pegan
Summary: In the past 20 years, both severe acute respiratory syndrome coronavirus-1 and severe acute respiratory syndrome coronavirus-2 have caused zoonotic outbreaks in humans. The PLpro enzyme from a subgroup 2b bat coronavirus has been studied to identify structural features and substrate specificity. Based on this, 30 novel noncovalent inhibitors for subgroup 2b PLpro enzymes were designed, providing new directions for antiviral development against this group of coronaviruses.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Samir Ghosh, Kevin R. Trabbic, Mengchao Shi, Sharmeen Nishat, Pradheep Eradi, Kristopher A. Kleski, Peter R. Andreana