Journal
TETRAHEDRON LETTERS
Volume 55, Issue 11, Pages 1859-1862Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.11.065
Keywords
Rh(III)-catalyzed; C-H activation; Indoles
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A practical Rh-catalyzed reaction was developed to achieve 2-alkyl-substituted indole synthesis. The reaction can tolerate a variety of synthetically important functional groups. The indole products can also be transformed into other important skeletons. Two bioactive compounds, that is indomethacin and pravadoline were prepared using the new method. (C) 2014 Published by Elsevier Ltd.
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