O-Aryloxime ether analogues as novel and efficient ligands for palladium-catalyzed Suzuki-Miyaura coupling in water

O-Aryloxime ether analogues L1-L3 were studied as ligands in palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl bromides and aryl boronic acids in water at room temperature. Reaction conditions for the cross-coupling were optimized using PdCl2 and Pd(OAc)(2) under aerobic condition. From the three electronically diverse O-aryloxime ether ligands studied herein, the use of 1-phenyl-ethanone O-(4-chloro-phenyl)-oxime L2 exhibits the best catalytic system in the presence of K2CO3 as the base and TBAB as the promoter. (C) 2014 Elsevier Ltd. All rights reserved.