Silica supported lanthanum Vitiate mediated synthesis of 5-substituted-1H tetrazoles

Silica supported lanthanum triflate (Ln(OTf)(3)-SiO2) promoted synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition between aromatic/heteroaromatic nitriles and sodium azide is a high product yielding, facile, and straightforward procedure. Non toxicity, recovery, and reusability for three continuous cycles are the noteworthy features of the currently employed heterogeneous catalyst. (C) 2014 Elsevier Ltd. All rights reserved.