4.4 Article

Bu4NI-catalyzed construction of C-O bonds by oxidative coupling of alcohols with ethers

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 34, Pages 4785-4789

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.06.103

Keywords

C-O bond; Oxidative coupling; alpha-Acyloxy ethers; Bu4NI; TBHP

Funding

  1. National Nature Science Foundation of China [21302013]
  2. Nature Science Foundation of Jiangsu Province [BK2012207]
  3. Nature Science Foundation of Jiangsu Educational Department [12KJA150001, 12KJB150001]

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A facile and efficient protocol for the construction of C-O bonds by oxidative coupling of alcohols with ethers has been realized in the absence of transition metals. The reaction was performed with a catalytic amount of n-Bu4NI and aqueous TBHP as an oxidant. A series of alpha-acyloxy ethers were obtained in good yields. (C) 2014 Elsevier Ltd. All rights reserved.

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