Review
Oncology
Paul A. Townsend, Maria Kozhevnikova, Olivier N. F. Cexus, Andrey A. Zamyatnin, Surinder M. Soond
Summary: Research on BH3 mimetics has led to significant advancements in cancer treatment and potential therapeutic applications in other diseases like cardiovascular conditions and tissue fibrosis, highlighting the importance of the apoptosis pathway in tissue homeostasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Engineering, Multidisciplinary
Valeria Lanza, Graziella Vecchio
Summary: This study synthesized novel glycoconjugates of salen complex and found that they exhibited higher SOD-like activity and other enzyme activities compared to EUK-108. In the presence of Ricinus communis agglutinin, the hybrid protein-galactose-EUK-108 system showed increased SOD-like activity.
Review
Chemistry, Multidisciplinary
Bole Li, Xiaotong Xu, Yanfei Lv, Zhaohui Wu, Lei He, Yu-Fei Song
Summary: Artificial enzymes based on polyoxometalates (POMs), a class of inorganic metal oxides, have shown great potential in mimicking enzyme activity due to their well-defined structure, tunable composition, high catalytic efficiency, and easy storage properties. This review summarizes recent progresses on the development and application of POM-based artificial enzymes, elucidates the corresponding catalytic mechanisms, and provides insight into the current challenges and the future directions for POMs-based artificial enzymes.
Article
Chemistry, Medicinal
Saqlain Haider, Patrice Penfornis, Pier Paolo Claudio, James D. McChesney, Amar G. Chittiboyina
Summary: TumorSelect (R) is a innovative anticancer technology that combines cytotoxics, nanotechnology, and knowledge of human physiology to deliver anticancer drugs specifically to tumor tissues with minimal side effects. By incorporating designer prodrugs into pseudo-LDL nanoparticles, the system can effectively inhibit cancer cell proliferation. The method shows promising results in both cell line screenings and in vivo tumor reduction efficacy studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pradip Shit, Samim Sahaji, Anup Kumar Misra
Summary: The reduction of diselenides using hydrazine monohydrate and potassium hydroxide, followed by treatment with glycosyl halides under a one-pot, two-step phase transfer reaction condition, resulted in high-yield formation of beta-selenoglycosides and selenium linked disaccharide derivatives with beta-glycosidic linkages.
CARBOHYDRATE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pedro Ramirez-Lopez, Carlos Martinez, Alejandro Merchan, Almudena Perona, Maria J. Hernaiz
Summary: This study presents an efficient chemical synthesis of multivalent glycodendrons that have different functional groups and levels of multivalency. These glycodendrons can be used as tools to find new active compounds against Dengue virus.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Hayata Fukuo, Tatsuya Suzuki, Junpei Shimabukuro, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Hiromune Ando
Summary: This study presents a facile synthesis method for novel seleno-glycolipids with various glycan and lipid moieties, marking the first synthesis of diseleno-glycolipids. The development of seleno-glycolipids for X-ray structural studies of membrane proteins has been hindered by difficulties in their chemical syntheses.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Marius Drexler, Philipp Haltenort, Thomas A. Zevaco, Ulrich Arnold, Joerg Sauer
Summary: Oxymethylene ethers (OMEs) are intensively researched, especially those of the CH3O(CH2O)(n)CH3 type. Oxymethylene dialkyl ethers (OMDAEs) have been studied to a lesser extent but exhibit properties similar to conventional diesel fuels. Tools for predicting properties have been developed based on experimental data.
SUSTAINABLE ENERGY & FUELS
(2021)
Article
Chemistry, Multidisciplinary
Andrew E. Graham, Liam A. Bailey, Takudzwa Bere, Thomas E. Davies, Stuart H. Taylor
Summary: Nanoporous aluminosilicate materials catalyze the formation of furaldehyde dimethyl acetal from methanol efficiently, and this reaction can be used for the production of biofuel additives.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Anrong Chen, Lili Xu, Zhenghong Zhou, Shiyin Zhao, Tianyi Yang, Feng Zhu
Summary: Radical glycosylation has emerged as a powerful method for synthesizing carbohydrate mimetics, with novel glycosyl radical precursors being identified for the synthesis of various glycosides. This review highlights recent advances in radical glycosylation and provides insights for future research directions.
JOURNAL OF CARBOHYDRATE CHEMISTRY
(2021)
Article
Chemistry, Organic
Di Wang, Fu-Rong Cao, Guangying Lu, Jiangmeng Ren, Bu-Bing Zeng
Summary: A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds was developed, featuring simple operation, mild reaction conditions, short reaction time, recyclable catalyst, and broad substrate scope with excellent yields.
Article
Pharmacology & Pharmacy
Peter J. Morone, Wei Yan, Jamie Adcock, Padmini Komalavilas, J. Mocco, Reid C. Thompson, Colleen Brophy, Joyce Cheung-Flynn
Summary: Research suggests that subarachnoid hemorrhage results in downregulation of signaling components in the NO-PKG pathway, causing vasospasm. Targeting the downstream effector VSP for treatment could be a novel therapeutic strategy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Julia Razlivina, Nikita Serov, Olga Shapovalova, Vladimir Vinogradov
Summary: Enzymes face challenges such as high cost, complex purification, and low stability. Developing low-cost artificial enzymes with comparable or higher effectiveness is desired. Computational approaches show success in modeling nanozyme activities, but require assumptions about the system. Machine learning offers an alternative way to predict material properties, even in complex systems. In this study, a user-friendly expandable database of over 300 inorganic nanozymes is developed, along with a random forest regression model for peroxidase activity prediction. The DiZyme resource, including the database, predictive algorithm, and visualization tool, is also created to promote novel nanozyme discoveries worldwide.
Review
Cell Biology
Narissa Parry, Helen Wheadon, Mhairi Copland
Summary: The BCL-2 proteins play a crucial role in regulating the intrinsic apoptotic pathway by balancing the prosurvival and proapoptotic members to activate BAX and BAK. Small molecule inhibitors targeting prosurvival proteins, known as 'BH3 mimetics,' have become an important approach in treating hematological malignancies, with the BCL-2-specific inhibitor Venetoclax showing significant success in AML treatment. As research into utilizing BH3 mimetics in myeloid leukemia treatment continues to expand, evaluating the current position in this field is increasingly important.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Organic
Ajaz Ahmed, Debaraj Mukherjee
Summary: This article presents a method for the stereoselective synthesis of orthogonally protected N-substituted beta-aminooxysugars from sugar epoxides and nitrones derived from aromatic aldehydes. Both ether- and ester-protected sugar epoxides can be used in the synthesis. The synthesized aminooxy sugars can react with aldehydes bearing or free reducing sugars under heating conditions to yield N-O-linked 1,1-/1,5/1,6-disaccharide mimetics in good yield.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Immunology
Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hajjaj H. M. Abdu-Allah, Yuki Suganuma, Akihiro Imamura, Hiromune Ando, Hiromu Takematsu, Hideharu Ishida, Takeshi Tsubata
Summary: CD22 is an inhibitory B cell coreceptor that regulates B cell development and activation by downregulating BCR signaling. CD45 plays a crucial role in CD22-mediated inhibition of BCR signaling, while disruption of ligand binding of CD22 enhances CD22 phosphorylation. SHP-1 is required for ligand-mediated regulation of CD22 and dephosphorylates CD22 as well as other substrates to enhance BCR signaling.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mikito Nakano, Shinya Hanashima, Toshiaki Hara, Kazuya Kabayama, Yuya Asahina, Hironobu Hojo, Naoko Komura, Hiromune Ando, Thomas K. M. Nyholm, J. Peter Slotte, Michio Murata
Summary: GM3 in the plasma membranes suppresses cell growth by preventing the autophosphorylation of the epidermal growth factor receptor (EGFR). The lateral interaction between GM3 and the transmembrane segment of EGFR disturbs the formation of active EGFR dimers.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Review
Chemistry, Multidisciplinary
Amol M. Vibhute, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hiromune Ando
Summary: Sialic acid is an important component of cell surface glycans, but its structure complexity and unique features make it challenging to isolate large quantities of pure sialoglycans from natural sources, leading to a focus on chemical synthesis methods. Despite the difficulties in alpha-glycosylation of sialic acid, various types of sialyl donors/acceptors have been developed for the synthesis.
Article
Biochemistry & Molecular Biology
Hayato Ozaki, Takuya Asano, Hide-Nori Tanaka, Naoko Komura, Hiromune Ando, Hideharu Ishida, Akihiro Imamura
Summary: This paper reports the chemical synthesis of polylactosamine fragments up to 22-mer using a blockwise synthetic approach. The synthesis of an octasaccharide of keratan sulfate glycan was achieved using large building blocks as glycosyl donors and acceptors. The coupling reaction between these building blocks facilitated the purification of glycosylated products.
CARBOHYDRATE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Erino Araki, Masaya Hane, Rina Hatanaka, Ryota Kimura, Kana Tsuda, Miku Konishi, Naoko Komura, Hiromune Ando, Ken Kitajima, Chihiro Sato
Summary: This study analyzed the features of three isoforms of St8sia5 and found that St8sia5-L is localized in the Golgi, while St8sia5-M and -S are localized in the ER. Furthermore, only cells expressing St8sia5-L showed an increase in the incorporation of exogenous GD3. These findings indicate that the localization of St8sia5 is crucial for its enzymatic activity.
GLYCOCONJUGATE JOURNAL
(2022)
Editorial Material
Biochemistry & Molecular Biology
Tatsuya Suzuki
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amol M. Vibhute, Hide-nori Tanaka, Sushil K. Mishra, Reina F. Osuka, Masamichi Nagae, Chizuko Yonekawa, Hiroaki Korekane, Robert J. Doerksen, Hiromune Ando, Yasuhiko Kizuka
Summary: This study aims to design novel inhibitors for GnT-V by chemically synthesizing a series of UDP-GlcNAc analogs and testing their inhibitory effects on GnT-V. The results show that although these analogs have modest inhibition potency, they exhibit a certain selectivity for GnT-V. Additionally, the docking models provide insights into the interactions and inhibitory mechanisms between these analogs and GnT-V.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biochemistry & Molecular Biology
Yu Hamaya, Naoko Komura, Akihiro Imamura, Hideharu Ishida, Hiromune Ando, Hide-Nori Tanaka
Summary: A protecting-group-free method for the synthesis of 0-glycosyl esters and aryl 0-glycosides was developed using the latent chemical reactivity of N-acetyl-D-glucosamine (GlcNAc) oxazoline. The method exhibits a wide substrate scope, good functional group tolerance, and can efficiently produce a novel class of GlcNAc-conjugated biomaterials and prodrug candidates.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Chanikarn Chantarasrivong, Ryu Okada, Yuuki Yamane, Xue Yang, Yuriko Higuchi, Miku Konishi, Naoko Komura, Hiromune Ando, Ryuji Yokokawa, Fumiyoshi Yamashita
Summary: Tumor spheroids with a perfusable vascular network were constructed to evaluate drug delivery systems targeting tumor vasculature. The results suggest that 3'-CE sLeX mimic liposomes are a promising carrier for targeting tumor vasculature, and proinflammatory cytokine treatment may be beneficial in pharmacokinetic studies.
DRUG METABOLISM AND PHARMACOKINETICS
(2022)
Article
Chemistry, Multidisciplinary
Rui Hagino, Keita Mozaki, Naoko Komura, Akihiro Imamura, Hideharu Ishida, Hiromune Ando, Hide-Nori Tanaka
Summary: Poly(ADP-ribosylation) is a protein post-translational modification that generates branched poly(ADP-ribose). Through the development of a synthesis method, the branched core structure of poly(ADP-ribose) was successfully synthesized. This method overcame synthetic challenges, including the construction of glycosidic bonds in the presence of purine base and the installation of phosphate groups.
Article
Biochemistry & Molecular Biology
Eriko Yamaguchi, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Sophie Groux-Degroote, Martina Muehlenhoff, Kenichi G. N. Suzuki, Hiromune Ando
Summary: Ganglioside GD2 is involved in the proliferation and migration of breast cancer cells. However, its role is not well understood due to the difficulty in observing its dynamic and transient domains called lipid rafts in cell plasma membranes. In this study, we synthesized a fluorescent analog of GD2, which exhibits raft-philic characteristics, and can potentially assist in the investigation of raft-associated interactions using single-molecule imaging techniques.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yuki Suganuma, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Hiromu Takematsu, Takeshi Tsubata, Hideharu Ishida
Summary: We developed a new synthetic method for the large-scale synthesis of CD22-interacting glycans, which will facilitate the search for potential CD22 inhibitors with therapeutic potential.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Shogo Hamajima, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Tsuyoshi Ichiyanagi, Hiromune Ando
Summary: Chemical synthesis of Kdo-containing glycans is important for developing vaccines against pathogenic bacteria. The alpha-stereoselective glycosidation of Kdo has been achieved using a macrobicyclic donor. In this study, the protection of the 4-OH group and the use of a selectively removable booster allowed the synthesis of the dimeric Kdo sequence.
Article
Chemistry, Organic
Shogo Hamajima, Naoko Komura, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Haruka Noguchi, Tsuyoshi Ichiyanagi, Hiromune Ando
Summary: We describe a method for alpha-selective glycosidation of 3-deoxy-D-manno-2-octulosonic acid (Kdo) using a macrobicyclic Kdo donor as the precursor of a bridgehead oxocarbenium ion. The stereoselectivity of the reaction is not affected by the substrate structure and reaction conditions.
Article
Biochemistry & Molecular Biology
Maina Takahashi, Naoko Komura, Yukako Yoshida, Eriko Yamaguchi, Ami Hasegawa, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Kenichi G. N. Suzuki, Hiromune Ando
Summary: Gangliosides, a type of glycosphingolipids, form dynamic structures with proteins in cell plasma membranes and play important roles in various biological processes. Using single-molecule imaging, we investigated the behavior of a lacto-series ganglioside and discovered its interactions with other important proteins.
RSC CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
