Journal
TETRAHEDRON LETTERS
Volume 55, Issue 14, Pages 2201-2207Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.02.050
Keywords
Thiamine hydrochloride; Cyano acetyl indole; One-pot; CTAB; Michael addition
Categories
Funding
- CSIR, New Delhi
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A thiamine hydrochloride (VB1) accelerated, one-pot synthesis of 2-amino-6-(1H-indol-3-yl)-4-arylpyridine-3,5-dicarbonitriles was achieved via four-component reaction of 3-cyanoacetyl indole, aromatic aldehydes, ammonium acetate, and malononitrile in aqueous micellar conditions by a Knoevenagel condensation reaction followed by Michael-addition, which upon cyclization and dehydration yielded the corresponding product in excellent proportion. (C) 2014 Elsevier Ltd. All rights reserved.
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