Journal
TETRAHEDRON LETTERS
Volume 55, Issue 32, Pages 4466-4474Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.06.064
Keywords
Fused isoindolones; Ninhydrin adducts; Microwave heating; Condensation reactions; Heterocycles
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Funding
- University Grant Commission (UGC)
- CSIR, New Delhi [02(0007)/11/EMR-II]
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A series of biologically important isoindolone embedded heterocycles such as tetracyclic 2,4-diamino-5-aryl-10-oxo-10H-1,10a-diazaindeno[2,1-a]indene-3-carbonitriles and tricyclic 1-aryl-3,5-dioxo-1H-imidazo-[3,4-b]isoindoles have been synthesized from an easily derived common intermediate, 3-(2'-hydroxyaroyl)-2,3-dihydroisoindol-1-ones. The significant advantages of the present methodologies are the use of simple and easily available starting materials and reagents, operational simplicity, and good yields of the products with high atom-economy. (C) 2014 Elsevier Ltd. All rights reserved.
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