Journal
TETRAHEDRON LETTERS
Volume 55, Issue 30, Pages 4086-4090Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.05.117
Keywords
Hericium erinaceum; Hericiaceae; Hericirine; Anti-inflammation
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Funding
- Priority Research Center Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology, Republic of Korea [2009-0093815]
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A novel ergosterol conjunction-type alkaloid, hericirine (1), was isolated from the dried fruiting bodies of Hericium erinaceum. The overall framework of 1 was isolated, and combined with hericerin and ergosterol. Its structure was elucidated based on spectroscopic analysis using 1D and 2D NMR, IR and HRESIMS techniques. We found that hericirine significantly inhibited protein expression of iNOS and COX-2 and reduced NO, PGE(2), TNE-alpha, IL-6 and IL-1 beta production in RAW264.7 cells exposed to LPS. (C) 2014 Elsevier Ltd. All rights reserved.
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