4.4 Article

An expedient synthesis of 3-alkylideneoxindoles by Ti(OiPr)4/pyridine-mediated Knoevenagel condensation

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 6, Pages 1183-1187

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.12.097

Keywords

3-Alkylideneoxindoles; Titanium enolates; Ti((OPr)-Pr-i)(4)/pyridine; Knoevenagel condensation

Funding

  1. National Research Foundation of Korea (NRF)
  2. Ministry of Education, Science and Technology [2012R1A1B3000541]

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3-Alkylideneoxindoles have been prepared in excellent yields from oxindole and carbonyl compounds via an in situ generated titanium enolate of oxindole. (Z)-3-Alkylideneoxindoles could be synthesized selectively as major products from unsymmetrical ketones. (C) 2014 Elsevier Ltd. All rights reserved.

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