Journal
TETRAHEDRON LETTERS
Volume 55, Issue 6, Pages 1218-1221Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.002
Keywords
Molecular probes; Sonogashira coupling; Knoevenagel reaction; Diazo coupling; Optical properties
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Funding
- Slovenian Research Agency [P1-0230]
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In this work, we report the synthesis, X-ray structures, and optical properties of two DDNP analogs containing an unsaturated spacer inserted between the donor N,N-dimethylamino group and the naphthalene ring. The new compounds have longer distances between the donor and acceptor groups and are intended to serve as molecular probes for the assessment of spatial and polarity requirements for binding to protein aggregates found in the central nervous system (CNS) of patients with neurodegenerative diseases. (C) 2014 Elsevier Ltd. All rights reserved.
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