4.4 Article

Synthesis of dihydropyrazolo[4,3-c]azepines via iodine-mediated intramolecular hydrative cyclization

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 45, Pages 6236-6239

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.09.073

Keywords

Iodine; Allylamine; Morita-Baylis-Hillman; Hydrative cyclization; Nitrogen heterocycle

Funding

  1. Council of Scientific and Industrial Research, New Delhi, India
  2. DST, New Delhi, India

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A straightforward approach to substituted dihydropyrazolo[4,3-c]azepines via I-2-mediated intramolecular hydration in pyrazole-based allylamines prepared from Morita-Baylis-Hillman adducts of 4-iodopyrazolealdehyes is described. (C) 2014 Elsevier Ltd. All rights reserved.

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