Journal
TETRAHEDRON LETTERS
Volume 55, Issue 10, Pages 1743-1748Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.109
Keywords
Spiro lactones; Green chemistry; Silica sulfuric acid; Solvent-free condition; Reusable solid acid support
Categories
Funding
- UGC
- CSIR, New Delhi, India
- CSIR, New Delhi [02(0007)/11/EMR-II]
- DST-FIST, India
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A highly efficient protocol for the library synthesis of biologically important 3H,3'H-spiro[benzofuran-2,1'isobenzofuran]-3,3'-diones has been developed by employing silica sulfuric acid (SSA) as solid acid support under solvent-free condition. The dual characteristics of SSA, as an activating agent as well as oxidizing agent, have been well exposed in these syntheses. The intrinsic advantages of the methodology are the use of solvent-free reaction condition without using any toxic reagents or metal catalyst, operational simplicity, recyclability of the solid support, good availability of the starting materials, and excellent yields which make the method attractive, economic, and 'benign by design'. (C) 2014 Elsevier Ltd. All rights reserved.
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