4.4 Article

Synthesis of α-phthalimido-α′-dithiocarbamato propan-2-ols via a one-pot, three-component epoxide ring-opening in water

Journal

TETRAHEDRON LETTERS
Volume 55, Issue 40, Pages 5454-5457

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.08.017

Keywords

Dithiocarbamate; Phthalimide; Propan-2-ols; Water; Catalyst-free

Funding

  1. Chemistry of Kharazmi University (formerly Tarbiat Moallem University)

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Regioselective ring-opening of the N-(2,3-epoxypropyl)phthalimide with in situ prepared dithiocarbamic acid in water is reported for the synthesis of a new family of alpha-phthalimido-alpha'-dithiocarbamato propan-2-ols. The present method is simple, EtOAc is used for work-ups and affords excellent yield of products. (C) 2014 Elsevier Ltd. All rights reserved.

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