Journal
TETRAHEDRON LETTERS
Volume 54, Issue 5, Pages 384-386Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.11.021
Keywords
Aza-Morita-Baylis-Hillman reaction; Cyclophanes; Organocatalysis; Planar chirality
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Grants-in-Aid for Scientific Research [24590006] Funding Source: KAKEN
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Several new planar chiral bifunctional phosphine compounds based on the [2.2]paracyclophane backbone with a pseudo-ortho substitution pattern have been synthesized and applied to the aza-Morita-Baylis-Hillman reaction. An enantiopure phosphine-phenol catalyst bearing an aryl group as a spacer connected to a phosphino group exhibited an exceptionally high reactivity (rt, 2-40 min) and good enantioselectivity (up to 85% ee). (C) 2012 Elsevier Ltd. All rights reserved.
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