Journal
TETRAHEDRON LETTERS
Volume 54, Issue 21, Pages 2674-2678Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.03.047
Keywords
Hydrogenation; Amide; Ruthenium complex; Alcohol; Amine
Categories
Funding
- MEXT
- IGER in chemistry at Nagoya University (NU)
- JSPS
- Grants-in-Aid for Scientific Research [13J03646] Funding Source: KAKEN
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A general method for catalytic hydrogenation of unactivated amides was achieved. During the catalyst induction period, a novel structural change was observed involving full hydrogenation of the interior unsaturated bonds of the pyridines of the Ru-containing catalyst precursor. Based on this observation, the mechanism of amide hydrogenation may involve a two-step pathway, wherein the Ru catalyst having an H-Ru-N-H functionality is generated in the first step, followed by the amide carbonyl group interacting with the outer, rather than the inner, sphere of the Ru catalyst. (c) 2013 Elsevier Ltd. All rights reserved.
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