Journal
TETRAHEDRON LETTERS
Volume 54, Issue 35, Pages 4675-4678Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.06.079
Keywords
Indolo[1,2-c]quinazoline; Domino reaction; Zinc bromide; Hydroamination; Cyclization
Categories
Funding
- National Science Foundation of China [20802034, 21032002]
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An efficient protocol to generate indolo[1,2-c]quinazolines from acyclic alkyne substrates by ZnBr2-promated domino hydroamination-cyclization has been established. The dichotomous properties of zinc salts involving alkynophilicity and oxophilicity assure a one-pot formation of five- and six-membered nitrogen-containing rings in the skeleton. (C) 2013 Elsevier Ltd. All rights reserved.
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