Journal
TETRAHEDRON LETTERS
Volume 54, Issue 24, Pages 3137-3143Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.04.015
Keywords
Phthalazinones; 2,3-Benzoxazin-1-ones; Isoindolinones; Ninhydrin; Microwave irradiation; Antimicrobials
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Funding
- CSIR
- UGC, New Delhi, India
- CSIR, New Delhi [02(0007)/11/EMR-II]
- DST-FIST, India
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Biologically important phthalazinones, 2,3-benzoxazin-1-ones and isoindolinones have been synthesized from easily available ninhydrin in good yields. The appropriate ninhydrin adducts 2,2,-diaryl-1,3-indanediones and 3-(diarylmethylene)isobenzofuranones were treated with various nucleophiles like hydrazine hydrate, hydroxylamine, and phenylhydrazin to accomplish the heterocycles. The synthesized compounds were assayed for their antibacterial activity and showed significant activity against both the selected Gram positive and Gram negative bacteria, suggesting possible scope of using as antimicrobials. (C) 2013 Elsevier Ltd. All rights reserved.
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