Journal
TETRAHEDRON LETTERS
Volume 54, Issue 44, Pages 5924-5926Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.08.120
Keywords
EPR; Trityl radical; Oximetry; RGD
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Funding
- Universite catholique de Louvain, the Fond de la Recherche Scientifique
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A stable RGD-conjugated triarylmethyl (TAM) radical 3 has been synthesized in a straightforward three-step sequence. CT-03 'the Finland trityl' which is a very popular contrast agent for electron paramagnetic resonance imaging has been covalently bound to the NH2-ending of a pentapeptide commonly used to target integrins and confers tissue selectivity. Moreover, this new TAM radical is stable and sensitive to molecular oxygen. (C) 2013 Elsevier Ltd. All rights reserved.
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