4.4 Article

RGD-conjugated triarylmethyl radical as probe for electron paramagnetic imaging

Journal

TETRAHEDRON LETTERS
Volume 54, Issue 44, Pages 5924-5926

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.08.120

Keywords

EPR; Trityl radical; Oximetry; RGD

Funding

  1. Universite catholique de Louvain, the Fond de la Recherche Scientifique

Ask authors/readers for more resources

A stable RGD-conjugated triarylmethyl (TAM) radical 3 has been synthesized in a straightforward three-step sequence. CT-03 'the Finland trityl' which is a very popular contrast agent for electron paramagnetic resonance imaging has been covalently bound to the NH2-ending of a pentapeptide commonly used to target integrins and confers tissue selectivity. Moreover, this new TAM radical is stable and sensitive to molecular oxygen. (C) 2013 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available