Journal
TETRAHEDRON LETTERS
Volume 54, Issue 15, Pages 2001-2005Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.02.003
Keywords
C-H activation; Isoquinolone; N-O bond cleavage; Organometallics; Pd-catalysis
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Funding
- Cultivation Foundation for the New Faculties from the Tianjin University [60302010]
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A practical one-pot procedure for the preparation of N-H isoquinolones has been developed. This 2-step process via C-H activation of N-alkoxyl benzamides and NaH-mediated dealkoxylation reaction has been demonstrated to be a high yielding alternative methodology for the efficient synthesis of a wide range of representative N-H isoquiolones. In addition, the experimental precedent supported mechanism of the dealkoxylation reaction was also proposed. (C) 2013 Elsevier Ltd. All rights reserved.
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