Journal
TETRAHEDRON LETTERS
Volume 53, Issue 13, Pages 1671-1674Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.01.097
Keywords
Reductive-Heck coupling; Iboga alkaloids; Indoloazepine; Heteroannulation; Palladium catalyst
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Funding
- DST, India
- CSIR, India
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A mild and efficient synthetic route to the iboga scaffold by employing reductive-Heck type annulation is described. The utility of this process is demonstrated by the direct access to the ibogamine, epiibogarnine and iboga-analogs. The cyclization precursors were readily obtained from 2-iodoaniline by heteroannulation reaction with suitable alkynes followed by iodination. (C) 2012 Elsevier Ltd. All rights reserved.
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