Journal
TETRAHEDRON LETTERS
Volume 53, Issue 4, Pages 449-452Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.11.075
Keywords
Hydration; Nitriles; Amides; Copper oxide; Acetaldoxime
Categories
Funding
- National Natural Science Foundation of China-NSAF [11076017]
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An efficient method for the selective hydration of nitrile to amide by employing inexpensive copper salt catalyst and commercially available acetaldoxime in environmentally friendly water is described. Under this protocol, nitriles including aromatic nitriles, heterocyclic nitriles and aliphatic nitriles were converted into the corresponding amides in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.
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