Article
Chemistry, Multidisciplinary
Rima D. Alharthy, Nadeem Ahmed, Saman Mubarak, Muhammad Yaqub, Muhammad Khalid, Iqra Shafiq, Muhammad Adnan Asghar, Ataualpa Albert Carmo Braga, Zahid Shafiq
Summary: A series of sensors, SM-1 to SM-3, were designed and synthesized using indole carboxaldehydes and 2,4-dinitrophenyl hydrazine. The synthesis was accompanied by a density functional theory investigation, which revealed a reduction in band gap, a bathochromic shift, and charge transference. SM-3 displayed high selectivity toward F- ions, with a low detection limit and a binding constant of 7.7 x 105.
Article
Chemistry, Multidisciplinary
Rima D. Alharthy, Nadeem Ahmed, Saman Mubarak, Muhammad Yaqub, Muhammad Khalid, Iqra Shafiq, Muhammad Adnan Asghar, Ataualpa Albert Carmo Braga, Zahid Shafiq
Summary: A new series of sensors (SM-1 to SM-3) were synthesized using indole carboxaldehydes and 2,4-dinitrophenyl hydrazine. The deprotonated chromophores exhibited a smaller band gap and a red shift compared to the neutral sensors. Charge transfer from indole to dinitrophenyl hydrazine was observed. Sensor SM-3 showed high selectivity for F- ions, while SM-1 and SM-2 responded to both F- and CN- ions.
Review
Chemistry, Inorganic & Nuclear
Nisha Jain, Navneet Kaur
Summary: Intensive development of 1,8-naphthalimide-based sensors in the past five years has led to wide and real-world applications for sensing metal ions, anions, and biomolecules. This comprehensive compendium provides valuable insights for researchers in the field of sensing and aims to facilitate the development of chemosensors with improved practical applications in the future.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Conor Geraghty, Conor Wynne, Robert B. P. Elmes
Summary: Fluorescent probes are essential tools in studying biological systems, and the 1,8-naphthalimide fluorophore is commonly used for detecting enzymatic conversions. With advancements in synthetic methods, the sensitivity and selectivity of these probes continue to improve.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Bhawna Rani, Neelam Sharma, Rahul Shrivastava, Arunava Agarwala, Ved Praksah Verma
Summary: A styryl-BODIPY based receptor (SBT) has been synthesized as a colorimetric chemosensor for selective sensing of CN- and Cu2+ ions. The receptor exhibited notable optical color changes in the presence of aqueous solutions of CN- and Cu2+ ions respectively. It showed a linear shift in absorption peak for sensing CN- ions and selective sensing of Cu2+ ions over other competitive cations with detection limits lower than the recommended concentration of Cu2+ in drinking water.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Vijay Kumar, Devender Singh, Pramod Kumar, Garima Chaudhary, Amit P. P. Singh, Rajeev Gupta
Summary: This study presents two rationally designed chemosensors, L1 and L2, which are capable of fluorescent detection of Ni2+ and Zn2+ ions. The coordination of Ni2+ and Zn2+ ions with the chemosensors leads to significant changes in their emission and absorption spectra. Competitive binding experiments, detection limits, and binding constants demonstrate the remarkable sensing abilities of L1 and L2 towards Ni2+ and Zn2+ ions.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Sabiha A. Shaikh, Satish S. Bhat, Pooja Lokesh Hegde, Vidyanand K. Revankar, S. Naveen, Karthik Kumara, N. K. Lokanath, Ray J. Butcher
Summary: A 2-amino-1H-benzo[de]isoquinoline-1,3-(2H)dione ligand (L) has been synthesized and forms a supramolecular metal-organic framework with various copper(II) salts. The complexes exhibit unique structures and properties in terms of coordination environment and fluorescence.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Yogajivan Rout, Rajneesh Misra
Summary: A series of multi-acceptor push-pull derivatives were designed and synthesized with different acceptor units to improve their photophysical and electrochemical properties, showing multiple redox waves in cyclic voltammetry.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Spectroscopy
Krishnaveni Karuppiah, Malini Nelson, M. Mujahid Alam, Manickam Selvaraj, Murugesan Sepperumal, Siva Ayyanar
Summary: A novel indole hydrazone tagged moiety BHDL has been developed for the selective and sensitive detection of biogenic tryptamine and F- ions. The binding mechanism of BHDL with tryptamine and F- ions has been investigated using spectroscopy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Sukriye Nihan Karuk Elmas, Fatma Nur Arslan, Duygu Aydin
Summary: A novel chemical sensor BUDIN based on 1,8-naphthalimide has been developed, which exhibits ratiometric fluorescence behavior and naked-eye response for sensitive and specific determination of Cu2+ at nanomolar levels. BUDIN shows continuous emission variations with the addition of different amounts of Cu2+, resulting in color changes from yellow to blue. The detection limit for Cu2+ is 17 nM.
Article
Chemistry, Analytical
Sanjeev Kumar, Neha Sharma, Satwinder Singh Marok, Satwinderjeet Kaur, Prabhpreet Singh
Summary: A chemosensor based on a naphthalimide compound has been developed for the detection of Pd2+ ions in solution. The compound exhibits aggregation induced emission enhancement and shows high sensitivity and selectivity towards Pd2+ ions. It has been successfully applied for intracellular detection and analysis of Pd2+ ions in biological samples, and can also be used as security ink for anticounterfeiting applications.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Jing Cao, Jiajia Gong, Nanyan Fu
Summary: The tyrosinase specific sensing probe NITYO was designed with recognition unit 3-hydroxy benzyloxy, which quenches the naphthalimide core via PET effect. The detection method achieved highly sensitivity and selectivity through comprehensive analysis such as molecular orbital analysis, molecular docking and HRMS. The probe also exhibited superb linear fitting and lower detection limit within the range of 10-400 U/mL.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Jagajiban Sendh, Jubaraj B. Baruah
Summary: This study describes two different forms of N-amino-1,8-naphthalimide polymorphs, one with a zig-zag chain of symmetry non-equivalent molecules. Nitrate salt and ionic cocrystal of N-amino-1,8-naphthalimide were prepared and structurally characterized. The self-assemblies of these compounds show distinguishable pi-stacks among the naphthalimide rings. The molar conductance values of copper and cadmium complexes in solution are lower than expected, possibly due to the large size of the cationic part in these complexes.
Article
Chemistry, Analytical
Ashwani Kumar, Virender, Brij Mohan, Alexander A. Solovev, Mohit Saini, Harish Kumar Sharma
Summary: In this study, a new chemosensor was synthesized for the sensitive and selective detection of Cu2+ and Pd2+ ions. The sensor showed visible color changes and could be applied as a detection assay on various substrates. The sensor also exhibited low detection limits, good association affinity, and reversible binding behavior towards the target metal ions. Infrared spectral analysis confirmed the binding behavior of the ligand towards selective metal ions.
MICROCHEMICAL JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Hanchuang Zhu, Caiyun Liu, Meijun Su, Xiaodi Rong, Yan Zhang, Xin Wang, Kun Wang, Xiwei Li, Yamin Yu, Xue Zhang, Baocun Zhu
Summary: The review discusses the recent progress in research on fluorescent probes, with a focus on the photophysical properties of 4-hydroxy-1,8-naphthalimide (HNI) structure and its applications in various fields. The aim is to develop more powerful fluorescent chemical sensors for a wider range of applications in the future.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Qi Tang, Ya-Ting Yu, Hai-Lin Zhang, Yi Wang, Jing Liu, Shi-Ping Yang, Jin-Gang Liu
Summary: The study synthesized a multifunctional nanoplatform capable of inhibiting histone deacetylases and releasing carbon monoxide to destroy mitochondria, inducing apoptosis in cancer cells. This targeted subcellular delivery of CO combined with inhibitory HDAC activity maximized the cytotoxicity of the nanoplatform, providing new insights into CO-mediated multimodal cancer treatment.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chao Li, Yucong Gao, Yuanyue Wang, Jie Wang, Jiaomin Lin, Jing Du, Zhiguo Zhou, Xiaoming Liu, Shiping Yang, Hong Yang
Summary: The synthesized IrPc-NPs nano-assembly exhibits bifunctionality, alleviating the hypoxia of tumor cells and improving the efficacy of sonodynamic therapy (SDT). It also shows excellent biocompatibility, benignancy towards overall tumor growth in vivo, and the controllability of timely applying ultrasound (US) irradiation during treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Ying Wan, Lu An, Zixuan Zhu, Qiwei Tian, Jiaomin Lin, Shiping Yang
Summary: Based on dendrimers, a series of polyphenol compounds (P1, P2, and P3) were coordinated with iron (III) (Fe3+) to investigate the effect of polyphenol structures on their T1 contrast performance. These new Fe3+-based complexes, featuring regular amplification of their phenolic hydroxyl groups, exhibit enhanced longitudinal relaxivity (r1) due to proton exchange facilitated by a hydrogen-bonding network. Furthermore, these designed Fe3+-based complexes demonstrate good T1 contrast effect in vitro and in vivo. Modifying the coordination structure of Fe3+-based contrast agents can potentially improve their relaxivity properties and facilitate the development of excellent magnetic resonance imaging agents for disease diagnosis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Fengfeng Xue, Shuntao Zhu, Qiwei Tian, Ruomeng Qin, Zerong Wang, Gang Huang, Shiping Yang
Summary: Magnetothermal therapy (MHT) is a promising non-/minimal invasive and efficient approach for tumor treatment. However, the development of small MHT agents (< 50 nm) with excellent magnetothermal conversion performance and high tumor enrichment remains challenging. In this study, a macrophage-mediated delivery system was designed for enhanced magnetic resonance imaging (MRI) and MHT of solid tumors using small Fe@Fe3O4-DHCA nanoparticles. The aggregation of Fe@Fe3O4-DHCA nanoparticles in macrophages resulted in enhanced MRI and magnetothermal performance in vitro. Moreover, the in vivo MHT effect of macrophages loaded with Fe@Fe3O4-DHCA was superior to that of Fe@Fe3O4-DHCA alone, attributed to the tumor-targeting capability of macrophages. This macrophage-mediated delivery system presents a new strategy for enhanced MHT based on Fe@Fe3O4-DHCA nanoparticles, with great potential for clinical tumor therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Yeping Liu, Likai Wang, Fengyuan Wei, Ya Tian, Juan Mou, Shiping Yang, Huixia Wu
Summary: In this study, a smart Mn3O4/OCN-PpIX@BSA nanoplatform was developed to enhance the combinational therapeutic efficacy of CDT and SDT through TME modulation. The nanoplatform effectively catalyzed endogenous H2O2 to produce O-2, relieved hypoxia, and generated oxidative stress by releasing Mn2+ ions. The results provide a new strategy for the construction of TME-regulating smart theranostic nanoagents.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Qi Yang, Yajun Yu, Chaojie Tang, Yucong Gao, Wu Wang, Zhiguo Zhou, Shiping Yang, Hong Yang
Summary: We developed iridium(iii)-cyanine complex/bovine serum albumin-based nanoparticles conjugated with folic acid, which can serve as a photoacoustic imaging probe for lymph node imaging. These nanoparticles exhibit good biocompatibility, strong near-infrared absorption, and impressive lymph node accumulation. Our study demonstrates the potential of this new photoacoustic imaging technique for real-time imaging and quantitative analysis of lymph nodes, providing a more efficient and reliable evaluation method for lymphadenectomy.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Likai Wang, Ya Tian, Kexin Lai, Yeping Liu, Juan Mou, Shiping Yang, Huixia Wu
Summary: Ultrasound-triggered sonodynamic therapy (SDT) has gained significant attention as a non-invasive and deep tissue penetration alternative for cancer treatment. However, the efficacy of SDT alone is limited by the hypoxic nature of solid tumors. Therefore, this study develops an intelligent theranostic nanoplatform that combines SDT and nitric oxide (NO) therapy to enhance cancer treatment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Hai -Lin Zhang, Yi Wang, Qi Tang, Bing Ren, Shi-Ping Yang, Jin -Gang Liu
Summary: A hollow mesoporous manganese dioxide-based multifunctional nanoplatform was developed for synergistic cancer treatment, which loaded a histone deacetylase inhibitor AFIPB in its hollow cavity and covalently decorated a ruthenium nitrosyl donor and a folic acid targeting group on its covered polydopamine layer. The nanoplatform exhibited tumor microenvironment-responsive properties and could deplete glutathione to disrupt the antioxidant defense system and deliver drugs on demand. Furthermore, it could generate highly toxic hydroxyl radicals through the catalysis of released Mn2+ and produce controlled nitric oxide delivery and significant photothermal effect under 808 nm light irradiation, resulting in high mortality of cancer cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Jing He, Wei He, Run Wang, Jingjing Jiao, Shiping Yang
Summary: We developed a nanoplatform for combined chemotherapy and enhanced chemodynamic therapy by self-assembling a water-soluble and amphipathic ferrous metallacage (FM), hydrophilic copolymer (PEG2000-COOH), and oxaliplatin (OXA). The FM acted as a catalyst for the Fenton reaction and potential agent for chemodynamic therapy. OXA not only served as an anti-tumor drug but also activated intracellular enzymes to enhance the chemodynamic therapy effect. In vitro and in vivo experiments demonstrated that FM@OXA-PEG showed minimal toxicity to normal cells, while effectively killing tumor cells and inhibiting tumor growth.
MATERIALS ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Kaiwen Chen, Xiangwei Wang, Xiaoping Xu, Xiao Wang, Simin He, Jianping Zhang, Yuyun Sun, Shiping Yang, Shaoli Song
Summary: A novel HER2-targeted PET imaging probe was successfully developed, showing significant potential for the detection of HER2 expression in tumors.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shasha Zhao, Kexin Lai, Zhen Gao, Xueli Ye, Juan Mou, Shiping Yang, Huixia Wu
Summary: This article introduces a clever combination of nano-enzymes and therapeutic drugs that can promote the production of reactive oxygen species (ROS) in cancer cells, enhancing the therapeutic efficacy of nanomedicines on malignant tumors. By loading the specific drug onto PEGylated Ce-doped hollow mesoporous silica nanoparticles, a smart nanoplatform is constructed to improve tumor therapy efficiency. The carrier showed multi-enzyme activities, with Ce3+ ions converting endogenous H2O2 into highly toxic OH for chemodynamic therapy and Ce4+ ions exhibiting catalase-like activity to reduce tumor hypoxia and glutathione (GSH) peroxidase-mimicking properties to effectively deplete GSH in tumor cells. Moreover, the loaded drug disrupts mitochondrial functions, causing the accumulation of superoxide anions (O-2(-)) and H2O2 within tumor cells. By combining the advantages of the carrier and the drug, the prepared nanoplatform can efficiently induce cancer cell death and inhibit tumor growth through significantly enhanced ROS production. Therefore, this positive combination therapy strategy has a promising application prospect for enhancing antitumor efficacy.
Article
Materials Science, Biomaterials
Minmin Liang, Weixiu Zhou, Haifeng Zhang, Jutian Zheng, Jiaomin Lin, Lu An, Shiping Yang
Summary: In this study, a pH- and glutathione (GSH)-responsive T-1-T-2 dual-mode contrast agent, Fe3O4@ZIF-8-Zn-Mn nanoparticles (NPs), was constructed to improve the sensitivity and accuracy of magnetic resonance imaging (MRI). The NPs showed good stability and weak T-1-T-2 dual-mode MRI contrast effect under neutral conditions, but could be disassembled and release Fe3O4 NPs and paramagnetic Mn2+ ions under acidic environment (pH = 6.5-5.5) and in the presence of GSH (0-4 mM), resulting in enhanced T-1 and T-2 imaging performances. In vivo MRI experiments demonstrated the potential of Fe3O4@ZIF-8-Zn-Mn NPs as a tumor microenvironment-responsive T-1-T-2 dual-mode contrast agent for sensitive tumor imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Jingjing Jiao, Jing He, Mengmeng Li, Jingxia Yang, Hong Yang, Xiaoqing Wang, Shiping Yang
Summary: In this study, an effective nanoplatform was designed to improve the efficacy of photodynamic therapy. The nanoparticle showed enhanced PDT efficacy by improving the stability of the photosensitizer, increasing intracellular accumulation, and relieving tumor hypoxia.
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
