Journal
TETRAHEDRON LETTERS
Volume 53, Issue 18, Pages 2292-2294Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.02.075
Keywords
Electrophilic N-amination; beta-Boc-hydrazino acids; beta-Boc-hydrazino esters; Modified amino acids; N-Boc-O-tosyl hydroxylamine; Azapeptides
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Terminal tert-butyloxycarbonyl (Boc) protected hydrazino acids, useful intermediates for modified peptides and biologically active heterocyclic derivatives, were synthesized by electrophilic amination methodology using N-Boc-O-tosyl hydroxylamine as an efficient NH-Boc transfer reagent. Also, we have demonstrated the conversion of other amino acid derivatives such as amino esters and amino alcohols into beta-Boc-hydrazino derivatives using this reagent. (C) 2012 Elsevier Ltd. All rights reserved.
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