Journal
TETRAHEDRON LETTERS
Volume 53, Issue 26, Pages 3346-3348Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.04.073
Keywords
Azaquinone; Phenylhydrazone; Streptomyces
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [22310133, 23404007, P09042]
- Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [23102008]
- MEXT
- Chiba University
- Grants-in-Aid for Scientific Research [23102008, 22310133, 23404007, 23710249] Funding Source: KAKEN
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An unusual alkaloid with a 2-azaquinone-phenylhydrazone structure, katorazone (1), and other metabolites were isolated from the ethyl acetate extract of Streptomyces sp. IFM 11299. The chemical structure of katorazone (1) was elucidated by 1D and 2D NMR analyses together with HR-ESI mass spectrometry. Katorazone (1) showed a synergistic effect in combination with TRAIL and decreased the viability of human gastric adenocarcinoma (AGS) cells. (C) 2012 Elsevier Ltd. All rights reserved.
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