4.4 Article

Palladium-catalyzed asymmetric hydrogenation of simple ketones activated by Bronsted acids

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 22, Pages 2826-2829

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.057

Keywords

Palladium; Asymmetric hydrogenation; Bronsted acid; Simple ketones

Funding

  1. National Science Foundation of China [20872140]
  2. National Basic Research Program [2010CB833300]
  3. Chinese Academy of Sciences

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Homogeneous Pd(OCOCF3)(2)/(R)-C-4-TunePhos has been successfully applied in the asymmetric hydrogenation of simple ketones activated by catalytic amount of Bronsted acid with up to 88% ee. (C) 2011 Elsevier Ltd. All rights reserved.

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