Journal
TETRAHEDRON LETTERS
Volume 52, Issue 19, Pages 2488-2491Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.021
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Funding
- National Natural Science Foundation [20802078, 20972160, 81071930]
- National Basic Research Program of China [2009CB940900, 2010CB529201]
- Chinese Academy of Sciences [KSCX2-YW-R-215, KSCX2-YW-R-235]
- National Major Scientific and Technological Program for Drug Discovery [2009ZX09103-101]
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The total synthesis of argyrins A and E were accomplished using a convergent strategy by condensation of one tripeptide and two dipeptide fragments. The synthesis strategy, which was developed for the protection of peptide fragments and identification of the optimum macrocylization site, can be applied to further synthetic studies involving other members of the argyrin family. (C) 2011 Elsevier Ltd. All rights reserved.
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