Journal
TETRAHEDRON LETTERS
Volume 52, Issue 50, Pages 6758-6762Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.025
Keywords
2,3-Alkylindoles; alpha-Diketones; Arylamines; Palladium catalysis; Chiral ligands
Categories
Funding
- DGAPA-UNAM [PAPIIT IN203209]
- SNI [340/5840]
- CONACyT [229448]
Ask authors/readers for more resources
A direct PdBr2(BINAP)-complex catalyzed method has been developed to produce 2,3-disubstituted indoles by the reaction of arylamines with alpha-diketones under reductive (H-2) conditions. The synthetic methodology involves a tandem reaction of three steps and all the organic intermediates were isolated and characterized, the reduction products in this sequence are chiral and present interesting enantiomeric excess. This report constitutes a new and different route to synthesize indoles and a plausible mechanism is also suggested. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available