Article
Chemistry, Multidisciplinary
Kuldeep Jaiswal, Naveen Malik, Boris Tumanskii, Gabriel Menard, Roman Dobrovetsky
Summary: In this study, the successful synthesis and characterization of the first persistent, formally 19-e Mo radical was achieved through photodissociation reaction, with the stabilization of the radical attributed to the unique electron-withdrawing effect of the o-carboranyl substituent at the phosphorus center.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biology
Remy A. Yovanno, Tsung Han Chou, Sarah J. Brantley, Hiro Furukawa, Albert Y. Lau
Summary: This study investigated the mechanisms of D-serine in receptor activation and found that D-serine competes with glutamate for binding to GluN2A. The inhibitory effect of D-serine at high concentrations was confirmed through electrophysiology experiments.
Article
Chemistry, Medicinal
Lea Ueberham, Daniel Guendel, Martin Kellert, Winnie Deuther-Conrad, Friedrich-Alexander Ludwig, Peter Loennecke, Aleksandr Kazimir, Klaus Kopka, Peter Brust, Rares-Petru Moldovan, Evamarie Hey-Hawkins
Summary: The synthesis and characterization of carborane-based 1,8-naphthyridinones and thiazoles as novel CB2R ligands was reported in this study. These compounds showed low nanomolar CB2R affinity, with LUZ5 exhibiting the highest affinity. An automated radiosynthesizer was used to obtain [18F]LUZ5-d8 with high radiochemical yield and purity. In vivo evaluation demonstrated the improved metabolic stability of [18F]LUZ5-d8 compared to [18F]JHU94620, and PET experiments in rats showed high uptake in spleen and low uptake in brain. The introduction of a carborane moiety is a useful strategy for modifying CB2R ligands and developing high-affinity CB2R ligands.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xin-Ran Liu, Peng-Fei Cui, Shu-Ting Guo, Run-Ze Yuan, Guo-Xin Jin
Summary: This study presents a controlled stepwise method for monitoring B-H bond activation based on meta-carborane, leading to the formation of various organometallic complexes through multiple reactions. The obtained palladium pincer complex exhibits acid-base responsive behavior, with reversible structural transformation between mononuclear and trimetallic forms.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Cell Biology
Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H. Eric Xu, Jia Duan
Summary: This study investigates the activation mechanism of HCAR2 by niacin and specific HCAR2 agonists using cryoelectron microscopy. The findings reveal that different ligands induce varying binding pockets in HCAR2, influenced by specific amino acid clusters. The study provides insights into ligand recognition, receptor activation, and G protein coupling, laying the groundwork for developing drugs targeting HCAR2.
Article
Chemistry, Inorganic & Nuclear
Chenshu Dai, Yuanyuan Huang, Jun Zhu
Summary: This study discusses the challenge of activating dinitrogen (N-2) under mild conditions and introduces the potential of using carborane derivatives for N-2 activation. Through theoretical calculations, it is found that carborane-based frustrated Lewis pairs (FLPs) have low reaction barriers and high exothermicity for N-2 activation, indicating the potential for metal-free N2 activation under mild conditions.
Article
Chemistry, Multidisciplinary
Chong Li, Matthew P. Aldred, Rachel A. Harder, Ying Chen, Dmitry S. Yufit, Ming-Qiang Zhu, Mark A. Fox
Summary: The dithienylethene molecule with carborane clusters exhibits exceptional fatigue resistance and vivid color changes under alternating UV and visible light. Its fluorescence can be toggled on and off in the solid state but not in solution.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Long Yang, Becky Bongsuiru Jei, Alexej Scheremetjew, Binbin Yuan, A. Claudia Stueckl, Lutz Ackermann
Summary: A copper-catalyzed electrochemical method for direct chalcogenation of o-carboranes has been established, allowing for high levels of position and chemo-selectivity control. This method provides an efficient means to activate inert cage C-H bonds for the late-stage diversification of o-carboranes.
Article
Pharmacology & Pharmacy
Shan Liu, Xiao-Bing Lan, Miao-Miao Tian, Chun-Hao Zhu, Lin Ma, Jia-Mei Yang, Juan Du, Ping Zheng, Jian-Qiang Yu, Ning Liu
Summary: Chronic pain poses a significant public health challenge, impacting patients' physical and psychological health as well as their quality of life. Current drug treatments for chronic pain often have limited efficacy and come with numerous side effects. The chemokine system, specifically the CCL2/CCR2 axis, plays a crucial role in the development and maintenance of chronic pain. Targeting this system through various approaches, such as siRNA, blocking antibodies, or small molecule antagonists, holds promise for managing chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhang, Zuowei Xie
Summary: o-Carboryne is a useful synthon for the synthesis of carborane-functionalized molecules, undergoing efficient cycloaddition reactions with various conjugated enynes. The reaction generates carborane-fused tricyclic compounds in moderate to high yields, providing a convenient strategy for the construction of complex carborane-functionalized molecules.
Article
Biochemical Research Methods
Yasunobu Asawa, Kei Nishida, Kazuki Kawai, Kiyotaka Domae, Hyun Seung Ban, Akihiro Kitazaki, Hiroya Asami, Jun-Ya Kohno, Satoshi Okada, Hiraku Tokuma, Daisuke Sakano, Shoen Kume, Masaru Tanaka, Hiroyuki Nakamura
Summary: Carboranes 1 and 2 were synthesized for degradation of HaloTag fusion proteins. The conjugation of carborane exposed lysine residues on BSA, leading to degradation via ubiquitin E3 ligase-related proteasome pathways in the cell.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ruoxi Xie, Zijun Wu, Fanxin Zeng, Huawei Cai, Dan Wang, Lei Gu, Hongyan Zhu, Su Lui, Gang Guo, Bin Song, Jinxing Li, Min Wu, Qiyong Gong
Summary: The study demonstrates that the use of MRI/NIR fluorescence dual-modal imaging nanoprobe can accurately locate and guide the precise excision of malignant gliomas in vivo. Both peptides/Cy7-SPIONs probes show excellent tumor-homing properties and barrier penetrating abilities, while (D)ANG/Cy7-SPIONs probes exhibit better enhanced MR imaging effects.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Bennett J. Eleazer, H. D. A. Chathumal Jayaweera, Gayathri B. Gange, Mark D. Smith, Corey R. Martin, Kyoung Chul Park, Alexey A. Popov, Dmitry Peryshkov
Summary: The synthesis of well-defined heterometallic complexes is a challenging frontier in inorganic chemistry. A new approach involving sequential insertion of electrophilic metal fragments into electron-rich Ru-B bonds has been reported, leading to the selective preparation of bimetallic and trimetallic complexes. Structural and theoretical analysis of chemical bonding features within Ru-B-B-Cu and Ru-B-B-Pd fragments were presented.
INORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Lijing Su, Muhammad Athamna, Ying Wang, Junmei Wang, Marina Freudenberg, Tao Yue, Jianhui Wang, Eva Marie Y. Moresco, Haoming He, Tsaffrir Zor, Bruce Beutler
Summary: Sulfatides can activate mouse immune responses via the TLR4-MD-2 complex, but exhibit antagonistic effects in human cells. Their activity is related to the presence of the sulfate group and the length of the fatty acid chain, and their structure mimics the activation mechanism of molecules like LPS in receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Nutrition & Dietetics
Natacha Rochel
Summary: This review provides an overview of the current knowledge about VDR structures and explores the recent progress in understanding the complex mechanism of action of 1,25D(3) from a structural perspective.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rossana Passannante, Vanessa Gomez-Vallejo, Unai Cossio, Jesus Ruiz-Cabello, Aitor Lekuona, Victor Salinas, Laura Amado-Rodriguez, Guillermo M. Albaiceta, Abraham Martin, Luka Rejc, Jordi Llop
Summary: The study investigates the use of radiofluorinated gas [F-18]SF6 as a PET ventilation marker in an animal model of impaired lung ventilation. The results show that [F-18]SF6 can accurately locate hypoventilated areas and may have implications in the early diagnosis of acute lung disease.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Environmental Sciences
Ellen Y. Cotrina, Angela Oliveira, Jordi Llop, Jordi Quintana, Xevi Biarnes, Isabel Cardoso, M. Silvia Diaz-Cruz, Gemma Arsequell
Summary: It has been found that several anthropogenic contaminants can compete with the thyroid hormone T4 for binding to the transport protein TTR, posing a potential threat to human health. In this study, a group of organic UV filters and paraben preservatives were investigated to identify their binding affinity to TTR. The results showed that a compound called BP2 had the strongest affinity to TTR, and computational studies were able to predict the binding modes of these chemicals to TTR. Further research on the involvement of TTR in the transfer of these chemicals across physiological barriers and the long-term consequences of prenatal exposure should be pursued.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
James Morgan, Oscar Moreno, Mariana Alves, Zurine Baz, Aida Menendez Mendez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke, Anindya Bhattacharya, Marc Ceusters, David C. Henshall, Vanessa Gomez-Vallejo, Jordi Llop, Tobias Engel
Summary: This study tested the P2X7R antagonist as a potential noninvasive biomarker of seizure-damage and epileptogenesis using PET imaging. The results showed that P2X7R levels correlated strongly with seizure severity in brain structures and peripheral organs, suggesting that P2X7R-based PET imaging could help identify seizure-induced neuropathology and patients who may benefit from P2X7R-based treatments.
Article
Engineering, Biomedical
Gabriela Arias-Alpizar, Panagiota Papadopoulou, Xabier Rios, Krishna Reddy Pulagam, Mohammad-Amin Moradi, Roy Pattipeiluhu, Jeroen Bussmann, Nico Sommerdijk, Jordi Llop, Alexander Kros, Frederick Campbell
Summary: Plasma lipid transport and metabolism are crucial for cellular function. A lipid nanoparticle formulation composed of two lipids can effectively be recognized and taken up by specific endothelial cell subsets through a lipase-mediated pathway. The liposome-lipase interaction is mediated by a unique liposome morphology. These compositionally simplistic liposomes provide new insights into the design of lipid-based nanoparticles for targeted delivery in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Microbiology
Marta Rua, Jon Ander Simon, Maria Collantes, Margarita Ecay, Jose Leiva, Francisco Carmona-Torre, Rocio Ramos, Felix Pareja, Krishna R. Pulagam, Jordi Llop, Jose Luis Del Pozo, Ivan Penuelas
Summary: This study tested two new radiotracers, [F-18]FDS and [F-18]FPABA, and examined their effectiveness in vitro and in an animal model. The results showed that [F-18]FDS can visualize Enterobacterales myositis infection and differentiate between yeasts with differential sorbitol assimilation. [F-18]FPABA was able to detect all tested bacteria and yeasts in vitro and distinguish between inflammation and infection in the animal model.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rossana Passannante, Vanessa Gomez-Vallejo, Maialen Sagartzazu-Aizpurua, Laura Vignau Arsuaga, Pablo Marco-Moreno, Garazi Aldanondo, Ainara Vallejo-Illarramendi, Pablo Aguiar, Unai Cossio, Abraham Martin, Jonas Bergare, Lee Kingston, Charles S. S. Elmore, Miguel Angel Morcillo, Pablo Ferron, Jesus M. M. Aizpurua, Jordi Llop
Summary: In this study, PET imaging was used to investigate the distribution, elimination, and metabolism of a triazole-based FKBP12 ligand (AHK2). The results showed that AHK2 binds to FKBP12 and exhibits stabilizing capacity. Pharmacokinetic studies revealed fast blood clearance, linear kinetics, and rapid metabolism of AHK2.
Article
Pharmacology & Pharmacy
Marc Bilbao-Asensio, Ane Ruiz-de-Angulo, Amaia Garaikoetxea Arguinzoniz, James Cronin, Jordi Llop, Aintzane Zabaleta, Saul Michue-Seijas, Dominika Sosnowska, James N. Arnold, Juan C. Mareque-Rivas
Summary: By modulating redox reactivity and ferroptosis, and utilizing nanoparticle-assisted lymphatic delivery, significant suppression of melanoma tumor growth can be achieved.
ADVANCED THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Laura Aguado, Ana Joya, Maider Garbizu, Sandra Plaza-Garcia, Leyre Iglesias, Maria Isabel Hernandez, Maria Ardaya, Naroa Mocha, Vanessa Gomez-Vallejo, Unai Cossio, Makoto Higuchi, Alfredo Rodriguez-Antiguedad, Mari Mar Freijo, Maria Domercq, Carlos Matute, Pedro Ramos-Cabrer, Jordi Llop, Abraham Martin
Summary: This study evaluated the effects of PHA 568487 on inflammation after cerebral ischemia using PET and MRI techniques. The activation of alpha 7 nAChRs resulted in a decrease of ischemic lesion, brain edema, and neurodegeneration. Treatment with PHA 568487 also improved the neurofunctional outcome and protected the integrity of the blood-brain barrier.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Chemistry, Multidisciplinary
Raul Cosialls, Odile Fernandez, Cristina Simo, Krishna R. Pulagam, Marta Guerra-Rebollo, Jordi Llop, Cristina Fornaguera, Ana B. Cuenca, Salvador Borros
Summary: Nucleic acid-based therapies have revolutionized pharmacology but face challenges in delivery due to their instability. Polymeric materials like poly(beta-aminoesters) (PBAEs) show promise as gene carriers, and PET-guided imaging provides insights into their pharmacokinetic profile. A new F-18-PET radiotracer based on a modified linear poly(beta-aminoester) was designed and synthesized, and its compatibility with polyplex formation and functional features was demonstrated. The observations support PBAEs as non-viral gene delivery vectors for future applications.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Cristina Simo, Cristian Salvador, Patrizia Andreozzi, Vanessa Gomez-Vallejo, Gabriela Romero, Damien Dupin, Jordi Llop, Sergio E. Moya
Summary: Polyamine-based vectors have potential for gene therapy, but more information is needed on their fate and efficiency for delivering nucleic acids. F-18 radiolabeled siRNA was complexed with different poly(allyl amine) hydrochloride (PAH) derivatives to form polyplexes, which were then injected into rodents. The biodistribution patterns differed depending on the polymer used for complexation. PAH and oleic acid-modified PAH polyplexes accumulated in the lungs and liver, while PAH(PEG) polyplexes accumulated in the kidneys and were eliminated through the bladder. The use of oleic acid-modified PAH resulted in limited availability of siRNA for tumor models.
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
