4.4 Article

Asymmetric sp3 C-H functionalization via a chiral Bronsted acid-catalyzed redox reaction for the synthesis of cyclic aminals

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 52, Pages 7064-7066

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.062

Keywords

Asymmetric catalysis; 1,5-Hydride shift; Bronsted acid; Cyclic aminals

Funding

  1. NSFC [20732006]
  2. MOST [2009CB82530]
  3. Ministry of Education
  4. USTC [WK2060190017]

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An organocatalytic asymmetric tandem 1,5-hydride transfer/ring closing reaction of o-aminobenzoketones with anilines to give cyclic aminals in fairly good diastereo- and enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.

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