An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indo1-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxo-thiazolidine-4-ones were prepared from the corresponding aromatic amines (la-e) and di-(carboxy-methyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acid chlorides (5a-d) using HSnBu(3). (C) 2011 Elsevier Ltd. All rights reserved.