Journal
TETRAHEDRON LETTERS
Volume 52, Issue 39, Pages 5004-5007Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.07.024
Keywords
S-Benzyl isothiouronium chloride; Reductive amination; Aldehydes; Recoverable organocatalyst
Categories
Funding
- Chonnam National University
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The direct reductive amination of aldehydes using S-benzyl isothiouronium chloride as a recoverable organocatalyst for the activation of the imine intermediate through hydrogen bonding is described. A mild and operationally simple fragment coupling procedure was accomplished with a wide range of aldehydes as well as amines in good to excellent yields. In addition, the S-benzyl isothiouronium chloride catalyst was easily recovered by simple filtration and reused without any drop in its efficiency. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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