Journal
TETRAHEDRON LETTERS
Volume 52, Issue 40, Pages 5117-5119Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.07.058
Keywords
Reductive amination; Catalytic hydrogenation; Tryptamine derivatives; Amine alkylation
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Formation of N-alkylated alpha-methyltryptamine derivatives (2) was accomplished by simple reductive amination of amine (1) with ketones using catalytic hydrogenation conditions (3 atm H(2) and 10% Pd on carbon). This method was also applied to other primary and secondary amines using ketones and aldehydes. (C) 2011 Elsevier Ltd. All rights reserved.
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