4.4 Article

Ionic liquid incorporated polystyrene resin for solid-phase peptide synthesis

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 13, Pages 1459-1461

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.01.067

Keywords

Ionic liquid; Anion exchange; Ionic liquid resin; Solid-phase peptide synthesis (SPPS)

Funding

  1. Ministry of Education, Science and Technology [R32-2008-000-10213-0]
  2. National Research Foundation of Korea [R32-2008-000-10213-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Ionic liquid (IL) resins with an ionic liquid environment on solid support were prepared by immobilizing ionic liquid spacers on polystyrene (PS) resin. The properties of IL resins were dramatically changed as the anions of IL were exchanged. The performance of IL resins for solid-phase peptide synthesis (SPPS) was evaluated by measuring coupling kinetics of the first amino acid and synthesizing several peptides on IL resins. (c) 2011 Elsevier Ltd. All rights reserved.

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