Article
Chemistry, Multidisciplinary
Mykhaylo Alekseychuk, Sinan Adrian, Robert C. Heinze, Philipp Heretsch
Summary: The chemical synthesis of spirochensilides and their rearrangement mechanisms in biosynthesis are reported, providing a new approach for the synthesis of other related natural products.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Yanan Wang, Yu Zhang, Wen Liu, Qiang Yu, Zhenni Liu, Shirui Xu, Jie An, Xiujie Li, Xiangxue Zhu
Summary: Here, an efficient and rapid synthesis strategy for MOR zeolite with the assistance of organic/inorganic additives is developed. The strategy effectively promotes the nucleation of MOR and benefits the recycling of the organic structure directing agent TEAOH. By this strategy, nano-sized MOR zeolite with large mesoporous volume is successfully synthesized.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Juan Wu, Xin-Yu Li, Ting-Rui Li, Ming-Zhen Shao, Li-Jing Niu, Xiao-Fan Lu, Jing-Lan Kan, Yan Geng, Yu-Bin Dong
Summary: This study reports the first-ever synthesis of COF using natural sunlight and demonstrates its application as a reusable photocatalyst for promoting light-driven oxidation reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Yuichiro Kawamoto, Hideki Kitsukawa, Toyoharu Kobayashi, Hisanaka Ito
Summary: The enantioselective total synthesis of nesteretal A was accomplished in 15 steps through biomimetic cascade hemiacetalizations, along with other key features like Sharpless asymmetric dihydroxylation, diastereoselective 1,2-addition, Pd-catalyzed ene-type cyclization, and stereoselective epoxidation to construct a complex structure containing multiple quaternary carbons.
Article
Engineering, Environmental
Haoyu Yin, Lihu Liu, Jinxing Ma, Changyong Zhang, Guohong Qiu
Summary: This study constructed an asymmetric flow-electrode electrochemical separation (AFES) system, which efficiently removes As(III) from groundwater. The system achieves this through self-alkalization and the adsorption of H+ on the cathode, resulting in the removal of As(V) predominantly. The system shows stability and superior removal performance.
Article
Chemistry, Organic
Nicholas A. Falcone, Aaron T. Bosse, Hojoon Park, Jin-Quan Yu, Huw M. L. Davies, Erik J. Sorensen
Summary: The enantioselective formal synthesis of (-)-aflatoxin B-2 from 4-methoxyphenylacetic acid has been achieved by producing a key carbon-carbon bond, a benzylic stereocenter, and two arene carbon-oxygen bonds in the course of three site-selective C-H functionalizations. The unprecedented carbonyl-directed acetoxylation of two arene C-H bonds described in this study occurs under mild conditions that preserve the configuration of a sensitive benzylic stereocenter.
Article
Chemistry, Applied
Daniel Herkommer, Sarah Hunter, Sean M. Lynn, David Manley, Philip Rushworth, Fiona Slater, John B. Strachan, Martin Woods
Summary: This study describes an improved method for synthesizing a human immunodeficiency virus maturation inhibitor. Key features of this method include the avoidance of chromium reagents and the use of novel oxidation reactions and aldehyde reactions to replace hazardous reagents, resulting in efficient synthesis and protection of reactants.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Engineering, Environmental
Qilei Yang, Qi Li, Lei Li, Yue Peng, Dong Wang, Yongliang Ma, Junhua Li
Summary: This study presents a novel alpha-MnO2-like rod catalyst prepared via an acid etching route, which exhibits significantly improved benzene oxidation activity, especially at lower temperatures. The excellent catalytic performance is attributed to the catalyst's low-temperature reducibility and abundant surface-active oxygen species, making it a promising alternative to commercial noble metal catalysts for the elimination of volatile organic pollutants.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Physical
Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin
Summary: A four-step chemoenzymatic strategy was designed to synthesize chloramphenicol, resulting in the highest time-space yield ever reported. The success of this approach highlights its advantage in the asymmetric synthesis of chloramphenicol.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Zhiquan Chen, Jian Liu, Lei Ni, Juncheng Jiang, Yuan Yu, Yong Pan
Summary: In this study, a continuous-flow synthesis strategy using microchannel reactors was proposed to enhance the safety and efficiency of industrial-scale methyl sulfone (MSM) production. By gradually optimizing the design parameters, the yield of MSM reached 95.3% and the average annual time yield was 18.36 t·a -1. The maximum overlimit temperature and overtemperature time in the continuous flow were controlled within 10°C and 20 seconds respectively. The microchannel continuous-flow amplification process greatly improved the productivity of MSM while ensuring a high yield, presenting a promising strategy for efficient and safe industrial-scale production of MSM.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Chemistry, Physical
Yuanyi Zhou, Haipeng Wang, Xuechen Liu, Di Zeng, Kefu Wang, Ling Zhang, Wenzhong Wang
Summary: Selective oxidation of ammonia nitrogen into N-2 over BiOCl with high N-2 selectivity (>97%) is reported based on chlorine radical chemistry. The efficient Cl- conversion into reactive chlorine species and Cl--mediated Mars-van Krevelen mechanism contribute to the enhanced reactivity of the catalytic performance.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Chemistry, Multidisciplinary
Xuan Kan, Jian-Cheng Wang, Zhi Chen, Jia-Qi Du, Jing-Lan Kan, Wen-Yan Li, Yu-Bin Dong
Summary: In this study, a novel type of chiral covalent organic frameworks (CCOFs) was reported for the first time, which can achieve enantioselective photocatalytic reactions. The researchers successfully applied this framework to the photooxidation reaction of sulfides to sulfoxides and the synthesis of (R)-modafinil.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Plant Sciences
Marius Aursnes, Karoline Gangestad Primdahl, David Liwara, Eirik Johansson Solum
Summary: Endolichenic fungi are an important source of natural products with diverse bioactivities. In this study, the synthesis of two naturally occurring alpha-pyrones, dothideopyrone E and F, isolated from the endolichenic fungus Dothideomycetes sp. EL003334, is presented. The outlined strategy involves Fu-Suzuki akyl-alkyl cross-coupling, MacMillan alpha-oxyamination, and Sato's pericyclic cascade process to construct the 4-hydroxy-2-pyrone ring system. The synthesized compounds were found to match the data of the isolated material.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyu Lin, Nanlian Li, Chenlong Zhu, Bingfeng Sun
Summary: An efficient synthesis of rivaroxaban has been achieved through a five-step sequence starting from 4-morpholinoaniline and (S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione, with an overall yield of 44%. This synthesis is concise, environmentally friendly, and cost-effective, providing a solid foundation for the development of a new synthetic process for rivaroxaban.
Review
Chemistry, Multidisciplinary
Long Min, Li-Ping Zhong, Chuang-Chuang Li
Summary: Steroids continue to play a significant role in organic chemistry, medicinal chemistry, and drug discovery. However, the synthesis of unusual rearranged steroids, particularly abeo-steroids with a medium-sized ring, remains a challenge. This Account summarizes the laboratory's efforts in the total synthesis of abeo-steroids using cycloaddition strategies, highlighting the efficiency and versatility of each strategy in constructing structurally complex abeo-steroid cores. The findings provide valuable insights for advancing the total synthesis of abeo- and related steroids.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Ummi Zulaiqha Hamid, Maw Shin Sim, Rhanye Mac Guad, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Ker Woon Choy, Ismail Muhamad Fareez, Srinivasa Reddy Bonam, Yuan Seng Wu
Summary: HOTTIP, a long non-coding RNA (lncRNA), plays a crucial regulatory role in GI cancer, affecting multiple aspects of cancer progression and chemoresistance, including cellular functions and molecular mechanisms. It also exhibits a higher diagnostic value compared to existing biomarkers, making it a potential novel therapeutic target and diagnostic biomarker in GI cancer treatment.
CURRENT MOLECULAR MEDICINE
(2022)
Review
Chemistry, Medicinal
Nurul Amirah Mohd Zaid, Mahendran Sekar, Srinivasa Reddy Bonam, Siew Hua Gan, Pei Teng Lum, M. Yasmin Begum, Nur Najihah Izzati Mat Rani, Jaishree Vaijanathappa, Yuan Seng Wu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria
Summary: This review provides a brief overview of the effects and mechanisms of ten selected natural products in the treatment of inflammatory, neoplastic, and infectious skin disorders. Most of the natural products show anti-inflammatory, antioxidant, antimicrobial, and anticancer effects. The findings suggest that natural products could be a cost-effective, well-tolerated, and safe treatment option for skin diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Biology
Pei Teng Lum, Mahendran Sekar, Siew Hua Gan, Srikanth Jeyabalan, Srinivasa Reddy Bonam, Nur Najihah Izzati Mat Rani, Ku-Marina Ku-Mahdzir, Lay Jing Seow, Yuan Seng Wu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria
Summary: Mangiferin, a natural product, exhibits therapeutic benefits against various kidney disorders in animal models through antioxidant responses and regulation of physiological functions. It is considered a safe reno-protective molecule that protects the kidneys by inhibiting inflammation and oxidative stress. Further clinical trials are needed to confirm its potential as a therapeutic agent for kidney disorders in humans.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Srinivasa Reddy Bonam, Camille Chauvin, Laurine Levillayer, Mano Joseph Mathew, Anavaj Sakuntabhai, Jagadeesh Bayry
Summary: This study reports that SARS-CoV-2 induces cytokine responses, particularly IL-13, in both resting and IL-3 primed basophils. However, the expression of surface markers associated with basophil activation and PD-L1 expression on basophils are not affected by SARS-CoV-2. The results suggest that basophil cytokine responses to SARS-CoV-2 might help reduce inflammation and promote antibody responses to the virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Talasila Bhanu Teja, Mahendran Sekar, Talasila Pallavi, Sivamma Mettu, T. E. Gopalakrishna Murthy, Nur Najihah Izzati Mat Rani, Pallaval Veera Bramhachari, Srinivasa Reddy Bonam
Summary: Artificial Neural Networks (ANN) are widely used in the pharmaceutical industry to mimic the brain's functioning and solve various problems by analyzing and transforming information.
JOURNAL OF YOUNG PHARMACISTS
(2022)
Article
Cell Biology
Srinivasa Reddy Bonam, Camille Chauvin, Mano J. Mathew, Jagadeesh Bayry
Summary: This study identifies IFN-gamma as one of the factors that induce PD-L1 expression in human basophils and demonstrates the importance of IL-3 priming in IFN-gamma-induced PD-L1 expression.
Editorial Material
Microbiology
Srinivasa R. Bonam, Haitao Hu, Jagadeesh Bayry
Summary: Severe COVID-19 patients show dysregulated expression of checkpoint molecules PD-1 and PD-L1, indicating that these molecules could be considered as prognostic markers and therapeutic targets in severe cases of COVID-19.
FUTURE MICROBIOLOGY
(2022)
Article
Cell Biology
Renee L. Hajnik, Jessica A. Plante, Yuejin Liang, Mohamad-Gabriel Alameh, Jinyi Tang, Srinivasa Reddy Bonam, Chaojie Zhong, Awadalkareem Adam, Dionna Scharton, Grace H. Rafael, Yang Liu, Nicholas C. Hazell, Jiaren Sun, Lynn Soong, Pei-Yong Shi, Tian Wang, David H. Walker, Jie Sun, Drew Weissman, Scott C. Weaver, Kenneth S. Plante, Haitao Hu
Summary: This study reports a nucleoside-modified mRNA vaccine expressing the viral nucleoprotein, which shows modest control of SARS-CoV-2 when administered alone. However, combining this vaccine with a clinically proven mRNA vaccine expressing the spike protein induces robust protection against both Delta and Omicron variants.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Srinivasa Reddy Bonam, Peter Paul Platenburg, Jagadeesh Bayry
Summary: In this study, the immunopotentiating mechanism of an oil-in-water emulsion-based vaccine adjuvant called LiteVax Adjuvant (LVA) was analyzed. The researchers investigated the effect of LVA and its components on the function of dendritic cells (DC), which play a crucial role in the immune response. They found that the component CMS significantly enhanced DC activation markers, cytokine secretion, and CD4(+) T cell responses. This study identified the unique role of CMS in LVA and proposed that LVA acts as a delivery system while CMS acts as an immunostimulatory agent.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Medicinal
Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad
Summary: There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Among these members, TM4SF1, TM4SF4, and TM4SF5 play crucial roles in cancer angiogenesis, progression, and chemoresistance. Targeting these TM4SF members has emerged as a promising strategy for cancer therapy.
Editorial Material
Immunology
Nitin K. Saksena, Pedro A. Reche, Srinivasa Reddy Bonam, Nicasio Mancini
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Sruthi Vijaya Retnakumar, Srinivasa Reddy Bonam, Haitao Hu, Jagadeesh Bayry
Review
Immunology
K. Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava, Haitao Hu, Srinivasa Reddy Bonam, Rajendra Kurapati
Summary: Lipid nanoparticles (LNPs) are an advanced technology for efficient in vivo delivery of exogenous mRNA, especially for COVID-19 vaccines. LNPs consist of four different lipids: ionizable lipids, helper or neutral lipids, cholesterol, and lipids attached to polyethylene glycol (PEG). This review presents recent advances and insights in LNPs design, composition, and properties, with a focus on COVID-19 vaccine development. The role of ionizable lipids in mRNA vaccines and the use of LNPs as effective delivery vehicles for vaccination, genome editing, and protein replacement therapy are discussed.
Article
Biochemistry & Molecular Biology
Chetan Ram, Shobhit Gairola, Shobhit Verma, Madhav Nilakanth Mugale, Srinivasa Reddy Bonam, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu
Summary: Nephropathy, the most common microvascular disorder in diabetes, is aggravated by oxidative stress and inflammatory response caused by persistent hyperglycemia. This study investigated the effects of biochanin A on inflammation, NLRP3 inflammasome activation, oxidative stress, and fibrosis in diabetic kidneys. The results showed that biochanin A improved renal function, reduced histological changes, and suppressed NF-kappa B/NLRP3 axis in diabetic rats. In vitro studies also demonstrated that biochanin A reduced oxidative stress and apoptosis in high-glucose-induced renal tubular epithelial cells. Additionally, it inhibited the upregulation of NLRP3 and its associated proteins and blunted TGF-beta/Smad signaling and collagen production. These findings suggest the potential role of biochanin A in attenuating diabetic nephropathy.
Review
Peripheral Vascular Disease
Nur Zulaikha Azwa Zuraini, Mahendran Sekar, Yuan Seng Wu, Siew Hua Gan, Srinivasa Reddy Bonam, Nur Najihah Izzati Mat Rani, M. Yasmin Begum, Pei Teng Lum, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria
Summary: Cardiovascular diseases are a major cause of morbidity and mortality worldwide, with nutritional fruits showing significant benefits in managing and treating these conditions. Pomegranate and grapes have been extensively studied and documented for their cardioprotective effects, highlighting the potential of incorporating these fruits into dietary supplements for consistent protection against CVDs.
VASCULAR HEALTH AND RISK MANAGEMENT
(2021)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
