Journal
TETRAHEDRON LETTERS
Volume 52, Issue 21, Pages 2687-2691Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.068
Keywords
Palladium; Amination; Cross-coupling; N-Substituted 1-aminoindoles; Homogeneous catalysis
Categories
Funding
- CNRS
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The selective synthesis of N-(hetero)aryl-1-aminoindoles 3 from the corresponding N-aminoindoles and (hetero)aryl halides using a catalyst combination of Pd-2(dba)(3) associated to Josiphos is described. By switching to Xantphos as the ligand, the alternate catalytic system allows the coupling to proceed efficiently for the preparation of symmetrical and unsymmetrical N,N'-diaryl-1-aminoindole derivatives in good yields. (C) 2011 Elsevier Ltd. All rights reserved.
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