4.4 Article

An efficient fluoride-mediated O-arylation of sterically hindered halophenols with silylaryl triflates under mild reaction conditions

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 22, Pages 2849-2852

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.124

Keywords

O-Arylation; Functionalized diaryl ethers; Benzyne chemistry; Silylaryl triflates; Mild reaction conditions

Funding

  1. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  2. Fundacko de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)

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The reaction between 2,6-dihalophenols and 2-(trimethylsilyl)aryl triflates in the presence of CsF using acetonitrile as solvent at room temperature led to the formation of functionalized diaryl ethers in very good yields. (C) 2011 Elsevier Ltd. All rights reserved.

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