4.4 Article

A synthetic ditryptophan conjugate that rescues bacteria from mercury toxicity through complexation

Journal

TETRAHEDRON LETTERS
Volume 51, Issue 47, Pages 6111-6115

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.09.047

Keywords

Tryptophan conjugate; Mercury sequestration; Mercury sensing; Fluorescence; Self assembly

Funding

  1. CSIR
  2. DST

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The synthesis of ditryptophan-pyridine conjugates and their binding to mercury ions is described. Conjugate 3 shows an excellent ability to sequester mercury from solution and rescue bacterial growth in a concentration-dependent survival assay. It is proposed that such compounds, composed primarily of bioessential/biodegradable components, could be potentially used as sequestrating agents for the removal of Hg(II) ions in detoxification strategies. (C) 2010 Elsevier Ltd. All rights reserved.

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