Article
Chemistry, Multidisciplinary
Aakanksha Gurawa, Manoj Kumar, Sudhir Kashyap
Summary: The developed protocol allows for selective deprotection of acetyl groups in a wide range of substrates, including carbohydrates, amino acids, natural products, heterocycles, and general scaffolds. The environmentally friendly reagent system used in this method enables clean transformations under ambient conditions.
Article
Chemistry, Multidisciplinary
Davide Arnodo, Eugenio De Nardo, Simone Ghinato, Salvatore Baldino, Marco Blangetti, Cristina Prandi
Summary: A straightforward and sustainable protocol for the tetrahydropyranylation of alcohols was reported using bioinspired acidic natural deep eutectic solvents (NADESs) as reaction media. The method allowed the preparation of tetrahydropyranyl ethers from primary, secondary, and tertiary alcohols with high chemoselectivity and short reaction times, without the need for additional catalysts and under air. The scalability and recyclability of the NADESs were also demonstrated, making it possible to perform multigram preparations of THP ethers with no loss of catalytic activity up to ten recycling steps. Telescoped, one-pot tetrahydropyranylation/nucleophilic acyl substitution transformations using the same eutectic mixture were also shown.
Article
Chemistry, Multidisciplinary
Danijela Lunic, Nil Sanosa, Ignacio Funes-Ardoiz, Christopher J. Teskey
Summary: Although challenges still exist, we have developed a simple and mild protocol that selectively reduces starting materials containing both more nucleophilic and more electrophilic groups at room temperature. This protocol is able to preserve the integrity of other functional groups.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Ge Gao, Xianbao Sun, Gaolin Liang
Summary: Photothermal therapy (PTT) has emerged as a promising anticancer strategy, with mild-temperature PTT showing great potential. However, the therapeutic efficacy of mild-temperature PTT is limited by its lower heat intensity, necessitating strategies to enhance its anticancer effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Parisa Shafiee, Seyed Mehdi Alavi, Mehran Rezaei, Farzad Jokar
Summary: Fe, Mn, La, Ce, and Ba-promoted 15 wt%Ni-12.5 wt%Co-Al2O3 catalysts show improved catalytic performance in CO2 methanation reaction, with the Fe-promoted catalyst exhibiting the highest catalytic activity. The study also evaluated the effect of calcination temperature, feed composition, and gas hourly space velocity (GHSV) on the catalyst performance, confirming the Fe-promoted catalyst's superior performance.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuting Bai, Meirong Han, Xiangrui Li, Sisi Feng, Liping Lu, Shengqian Ma
Summary: A composite photocatalyst based on a cerium(iii) metal-organic framework, graphene oxide, and Fe3O4 was constructed, achieving a superior synergistic effect and improved photocatalytic performance. The composite exhibited high stability and could be easily recovered through magnetic separation.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Energy & Fuels
Yi Chen, Yongsheng Zhang, Wei Lin, Xianglin Cheng, Jianshe Wang, Xiaolong Liu, Chunbao Charles Xu, Renfeng Nie
Summary: In this study, two-dimensional Co-Al hydrotalcite catalysts were successfully fabricated for the conversion of biomass to value-added chemicals under mild conditions. The optimized CoAl-LDO600 catalyst achieved a high yield (94.2%) of octadecanol from oleic acid using iso-propanol as hydrogen donor at 200 degrees C. This catalyst exhibited excellent magnetic separability, stability, and versatility for various fatty acids with alcohol yields ranging from 89.1% to 96.7%.
Article
Chemistry, Organic
Chatrasal S. Rajput, Shweta Srivastava, Ashish Kumar, Arunendra Pathak
Summary: A new method has been developed for the preparation of dihydroquinazolin-4(1H)-ones from anthranilamide and aromatic aldehydes using the Mukaiyama reagent. The reactions proceed smoothly with high yields, low environmental impact, and high atom economy. The metal-free condition and ease of product isolation are highlighted advantages in addressing trace metal contamination in synthesized pharmaceuticals.
TETRAHEDRON LETTERS
(2021)
Article
Multidisciplinary Sciences
Ting Huang, Ruyi Lin, Yuanqin Su, Hao Sun, Xixi Zheng, Jinsong Zhang, Xiaoyan Lu, Baiqin Zhao, Xinchi Jiang, Lingling Huang, Ni Li, Jing Shi, Xiaohui Fan, Donghang Xu, Tianyuan Zhang, Jianqing Gao
Summary: The use of high-powered mesenchymal stem cells for efficient mitochondrial delivery can restore impaired mitochondrial homeostasis, recover cellular functions, and successfully mitigate the progression of pulmonary fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Energy & Fuels
Haoyue Fu, Weixin Qian, Haitao Zhang, Hongfang Ma, Weiyong Ying
Summary: Unmodified Cr/Al2O3 and Cr/Al2O3 doped with different alkali metals (Li, Na, K) were prepared using the incipient wetness impregnation method. The surface elements of all catalysts were evenly distributed and well loaded, and the addition of alkali metals did not alter the crystal structure and surface texture. Both Cr6+ and Cr3+ species were present on all catalysts, and the addition of alkali metals increased the amount of Cr6+ species, which were mainly converted into active Cr3+ species during the reaction, thereby enhancing the initial propane conversion. The addition of alkali metals reduced the total acid sites and strong acid sites of the catalyst, inhibiting side reactions and carbon deposition, and reducing catalyst deactivation. Cr-0.5Na/Al2O3 exhibited the best catalytic performance and the lowest carbon deposition.
Article
Chemistry, Organic
Chang Yoon Lee, Sung-Gon Kim
Summary: This study presents a novel and efficient method for the nucleophilic alpha-hydrolysis of alpha-halohydroxamates with water under metal-free conditions. The use of dimethyl sulfoxide (DMSO) as a catalyst and water as both nucleophile and oxygen source allowed for successful synthesis of various hydroxylated compounds. The method represents a mild, less toxic, and facile strategy for amide alpha-hydroxylation.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Energy & Fuels
Luqman Abdullahi Sani, Chao Wang, Mengjuan Zhang, Haolong Bai, Ping An, Zhennan Han, Lei Shi, Kangjun Wang, Dingrong Bai, Guangwen Xu, Fabing Su, Zhanguo Zhang
Summary: Introducing Yb modification in the preparation of Ni/Al2O3 catalysts promotes the dispersion of reducible NiO on Al2O3 and leads to the creation of new Yb-involved CO2 chemisorption sites. The Yb-modified Ni/Al2O3 catalysts exhibit higher catalytic activities and stability than the Ni/Al2O3 catalysts without Yb.
Article
Energy & Fuels
Andreina Alarcon, Olatz Palma, Elena Martin Morales, Marti Biset-Peiro, Teresa Andreu, Jordi Guilera
Summary: This study evaluated a series of bimetallic Co-X (X = Ni, Pt, and Fe) catalysts supported on La2O3 promoted Al2O3 micro-spheres, and verified that the incorporation of nickel is beneficial for high-calorie gas applications. Additionally, the utilization of CO as a carbon source was found to improve both conversion and C-1-C-4 hydrocarbon selectivities. An adapted reactor concept using a dual bimetallic catalyst and different reaction conditions is proposed to shift selectivity towards the targeted products.
Article
Engineering, Environmental
Mude Zhu, Xueqin Chen, Yi Tang, Sen Hou, Yang Yu, Xiaoyun Fan
Summary: This study presents a newly developed strategy that combines piezoelectric effect and persulfate activation for the removal of refractory emerging contaminants. It was found that the piezoelectric material SBBO can efficiently activate persulfate under ultrasonic irradiation, leading to the accelerated degradation of sulfadiazine. The PS/SBBO/US system shows excellent removal efficiency in various water bodies containing sulfadiazine.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ziqi Su, Hongxin Chai, Juan Xu, Jiarong Li
Summary: This method utilizes ZnCl2 to promote the synthesis of 1,3-benzoxazin-4-ones from 2-hydroxybenzonitriles and ketones, providing a high yield of substituted 1,3-benzoxazin-4-ones. It offers easy access to starting materials and eliminates the need for strong corrosive acids.
Article
Chemistry, Analytical
Jimei Ma, Heng Zhang, Fangfang Peng, Xiaoqing Yang, Zi-Long Li, Linhao Sun, Hong Jiang
ANALYTICA CHIMICA ACTA
(2020)
Article
Chemistry, Organic
Feiqing Ding, Akihiro Ishiwata, Siai Zhou, Xuemei Zhong, Yukishige Ito
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Adam T. Guy, Feiqing Ding, Junpei Abe, Mariko Inoue, Yoshio Hirabayashi, Yukishige Ito, Hiroyuki Kamiguchi, Peter Greimel
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Chemistry, Organic
Siai Zhou, Xuemei Zhong, Aoxin Guo, Qian Xiao, Jiaming Ao, Wanmeng Zhu, Hui Cai, Akihiro Ishiwata, Yukishige Ito, Xue-Wei Liu, Feiqing Ding
Summary: This study presents a glucosylation strategy using ZnI2 for stereoselective construction of 1,2-cis-O-glycosidic linkages. The versatility of this approach was demonstrated with various acceptors, including complex alcohols, indicating the potential for modular synthesis of various alpha-glucans.
Article
Chemistry, Medicinal
Qianqian Li, Zhimei Li, Nan Deng, Feiqing Ding, Yiliang Li, Hui Cai
Summary: This review primarily focuses on chemically synthesized compounds that can be used as built-in adjuvants, with a classification based on the induced immune activation mechanism and their application in various vaccine types.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Xuemei Zhong, Siai Zhou, Jiaming Ao, Aoxin Guo, Qian Xiao, Yan Huang, Wanmeng Zhu, Hui Cai, Akihiro Ishiwata, Yukishige Ito, Xue-Wei Liu, Feiqing Ding
Summary: The study presents a strategy for direct mannosylation mediated by ZnI2, allowing for highly stereoselective construction of 1,2-cis-beta linkages, which can be applied to various alcohol acceptors for beta-mannosylation and modular synthesis of trisaccharides for N-glycan synthesis. Theoretical investigations using density functional theory calculations elucidated the mechanistic details of this beta-selective mannosylation.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Xiaoya Zhao, Yan Huang, Siai Zhou, Jiaming Ao, Hui Cai, Katsunori Tanaka, Yukishige Ito, Akihiro Ishiwata, Feiqing Ding
Summary: Glycosylation is a major form of protein post-translational modification, and N-glycans play a crucial role in intercellular interaction and immune function. Efficient methods to provide homogeneous complex-type N-glycans have been urgently needed for analytical and medicinal purposes. Significant progress has been made in both chemical and chemoenzymatic strategies for the synthesis of N-glycans.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Siai Zhou, Jiaming Ao, Aoxin Guo, Xiaoya Zhao, Nan Deng, Guoqing Wang, Qixuan Yang, Akihiro Ishiwata, Xue-Wei Liu, Qianqian Li, Hui Cai, Feiqing Ding
Summary: A versatile ZnI2-directed fi-galactosylation approach using a 4,6-O-tethered and 2-O-Bn galactosyl donor is reported for the stereoselective and efficient synthesis of fi-O-galactosides. The reaction tolerates a wide range of functional groups and complex molecular architectures, providing stereocontrolled fi-galactosides in moderate to excellent yields. The practicality of this transformation is demonstrated through the synthesis of a tetrasaccharide arabinogalactan fragment with high stereoselectivity.
Review
Chemistry, Multidisciplinary
Akihiro Ishiwata, Katsunori Tanaka, Jiaming Ao, Feiqing Ding, Yukishige Ito
Summary: 1,2-cis-O-glycosylation is essential in the assembly of bioactive glycans with various functions. However, controlling the stereoselectivity of glycosylation and specifically forming 1,2-cis glycosides is challenging. Recent advances in glycosyl donor modification, reaction conditions, and activation methods have been made in the development of 1,2-cis selective glycosylations.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Yang Zhou, Qianqian Li, Ye Wu, Xinyu Li, Ya Zhou, Zhu Wang, Hui Liang, Feiqing Ding, Sheng Hong, Nicole F. Steinmetz, Hui Cai
Summary: Self-assembly is a widely used method for constructing biomaterials, and peptides have been extensively investigated due to their desirable properties. Stimuli-responsive peptide nanoparticles, capable of conformational and chemical changes in response to stimuli, have emerged as a promising class of materials with diverse biomedical applications.
Review
Biochemistry & Molecular Biology
Lixin Yin, Yang Zhou, Sheng Hong, Feiqing Ding, Hui Cai
Summary: Cancer vaccines harness the patient's immune system to induce a specific immune response to kill cancer cells. Glycoprotein mucin 1 (MUC1) is a promising candidate for cancer vaccines but faces challenges due to poor immunogenicity. Conjugation with immune activators is necessary. This review focuses on MUC1 glycopeptide synthesis, advanced vaccine designs, and a comparison of different strategies.
Article
Chemistry, Multidisciplinary
Yuhua Liu, Difei Liu, Senyu He, Xiaofeng Huang, Feiqing Ding, Yang Zhang
Summary: The mechanism of nickel-catalyzed selective hydroalkylation of 2-aryl-1,3-dienes was investigated using DFT calculations. The rate-determining step was found to be the ligand-to-ligand hydrogen transfer (LLHT) process. The LLHT step exhibits the lowest activation barrier when hydrogen transfers to the least sterically hindered position of the diene, forming a stable allylic-Ni intermediate. The subsequent nucleophilic attack leads to regio-divergent products depending on the substrate type, with steric effects playing a role in product selectivity.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Xuemei Zhong, Xiaoya Zhao, Jiaming Ao, Yan Huang, Yuhua Liu, Siai Zhou, Bizhi Li, Akihiro Ishiwata, Qianglin Fang, Chongguang Yang, Hui Cai, Feiqing Ding
Summary: This study presents a one-pot strategy for stereocontrolled glycosylation to generate both alpha- and beta-glycosides by altering reaction conditions. The selective formation of beta-glycosides was achieved by activating the perbenzylated trichloroacetimidate with a catalytic amount of SnCl4 at -40 degrees C. On the other hand, alpha-glycosides were obtained as the major products at room temperature by using 3.0 equivalents of SnCl4 and/or TiCl4. Control experiments and DFT calculations provided mechanistic insights into the glycosylation reaction, revealing a sequential occurrence of beta-glycosylation and anomerization.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Yuhua Liu, Feiqing Ding, Yixing Chen, Wenji Wu, Yusen He
Summary: DFT calculations were conducted on the Pd-catalyzed regioselective hydroaminocarbonylation of alkenes, revealing the significant impact of ligand electronic and steric effects on selectivity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Junpei Abe, Adam T. Guy, Feiqing Ding, Peter Greimel, Yoshio Hirabayashi, Hiroyuki Kamiguchi, Yukishige Ito
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
