Journal
TETRAHEDRON LETTERS
Volume 51, Issue 17, Pages 2309-2311Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.02.128
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Funding
- Department of Science & Technology Government of India [SR/FTP/CS-99/2006]
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An efficient and regioselective N-alkylation of 4(3H)-pyrimidone with various electrophiles in the presence of Fe nano particle is reported. The catalyst initiates N-alkylation of amides by alkyl chlorides. The reaction of equimolar 4(3H)-pyrimidone and 2-chloro-3-(chloromethyl)quinolines in the presence of KOH and Fe nano particle (5 mol %) m DMSO solution under reflux condition formed 3-[(2-chloroquinolin-3-yl]methyppyrimiclin-4(3H)ones. (C) 2010 Elsevier Ltd. All rights reserved.
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