A novel synthesis of 1,5-disubstituted fluorinated tetrazoles from 1,1-difluoroazides

A new one-step reaction between 1,1-difluoroazides and primary amines is reported as an efficient synthetic approach for tetrazole formation. Examples include the syntheses of fluorine-containing 1,5-substituted tetrazoles from three fluorinated azide precursors and various amines. Greater substituent diversity in comparison with conventional methods is achieved. (C) 2010 Elsevier Ltd. All rights reserved.