Journal
TETRAHEDRON LETTERS
Volume 50, Issue 48, Pages 6715-6719Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.096
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Funding
- National Science Foundation of China [20942001]
- Guangzhou Institutes of Biomedicine and Health (GIBH)
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A highly efficient one-pot synthesis of 2-chloro-3-substituted quinolines has been developed by tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes, which are generated in situ by dehydration of the corresponding N-(2-ethynylphenyl)formamides. (C) 2009 Elsevier Ltd. All rights reserved.
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