Article
Chemistry, Multidisciplinary
Marina S. Borisova, Dmitry I. Ivankin, Dmitry N. Sokolov, Olga A. Luzina, Tatjana Rybalova, Tatjana G. Tolstikova, Nariman F. Salakhutdinov
Summary: New thiazolidinones, thiazinanones, and thiazolidinediones based on a monoterpenoid (-)-campholenic aldehyde were synthesized and their antiulcer and anti-inflammatory activity was investigated. Thiazolidinones and thiazinanones containing (-)-campholenic moiety exhibited antiulcerogenic properties, while thiazolidinediones did not show antiulcerative activity. One of the (-)-campholenic aldehyde-derived thiazolidinones displayed high anti-inflammatory activity.
Article
Chemistry, Multidisciplinary
Chuan-Kun Ran, Lei Song, Ya-Nan Niu, Ming-Kai Wei, Zhen Zhang, Xiao-Yu Zhou, Da-Gang Yu
Summary: This study demonstrates the simultaneous utilization of elemental sulfur and CO2 in a multi-component reaction to generate valuable products efficiently. The transition-metal-free reaction conditions allow for the conversion of readily available arylamines to thiazolidin-2-ones and 1,3-thiazinan-2-ones through C-H bond functionalization, showcasing high step economy and good functional groups tolerance.
Article
Chemistry, Applied
Daokai Xiong, Zhengjie Zhang, Jing Zhang, Yurong Wang, Jianguo Yang, Zhiming Wang, Pengfei Zhang
Summary: Hexafluoroisopropanol (HFIP) is widely used as a versatile reaction media in organic synthesis, but its application as a catalyst has been rarely explored. This study presents the HFIP-catalyzed Mannich-type reaction between quinoxalin-2(1H)-ones and difluoroenoxysilanes. The developed protocol allows for the incorporation of various substituents under mild reaction conditions, providing a divergent approach to the synthesis of difluoro-substituted 3,4-dihydroquinoxalin-2(1H)-ones and monofluoroquinoxalin-2(1H)-ones in yields of 51-92%.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Mohd Nazeef, Km Neha Shivhare, Shabir Ali, Saif Ansari, I. R. Siddiqui
Summary: A new metal-free approach to construct medicinally valuable compounds under visible light irradiation in aqueous ethanol medium has been developed. This synthesis method offers lower cost, simplicity of operation, short reaction time, and high yield under mild reaction conditions.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Organic
Zhenjie Qi, Simiaomiao Wen, Zhao Liu, Dongfang Jiang
Summary: A synthetic strategy to pyridazin-4(1H)-ones/oxazin-4(1H)-ones has been developed through an oxidative 6-endo-trig cyclization and [2+2] cycloaddition of β,γ-unsaturated hydrazones/ketoximes and diazonium tetrafluoroborates under metal-free conditions. This method demonstrates excellent functional group tolerance and remarkable regioselectivity. Mechanistic studies using O-18 and H-2O-18 labeling confirm the involvement of O-2 as both a reaction component and an oxidant.
Article
Chemistry, Multidisciplinary
Mariia B. Litvinchuk, Anton V. Bentya, Eduard B. Rusanov, Mykhailo V. Vovk
Summary: A preparatively convenient and efficient synthetic route to new 5H-[1,3]thiazolo[3,2-c]pyrimidine derivatives has been described, using cyclocondensation of acyl or alkoxycarbonyl alpha-functionalized 2-methylidene-1,3-thiazolidin-4-ones with 1-chlorobenzyl isocyanates. The synthesized compounds have been structurally determined through elemental analysis, spectroscopic methods, and X-ray diffraction analysis. Some byproducts were also observed in the reaction, alongside the desired products.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Chemistry, Organic
Bingqing Wang, Hua Yao, Xiaoyang Zhong, Zhaohua Yan, Sen Lin
Summary: An efficient direct alkylation reaction of quinoxaline-2(1H)-ones with aldehydes was developed under metal-free conditions using DTBP as a promoter. The reaction involves sequential decarbonylation and radical addition, utilizing aliphatic aldehyde as a cheap and abundant alkyl radical source. This provides a convenient and efficient approach for synthesizing various 3-alkylquinoxaline-2(1H)-ones.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Emily E. Freeman, Randy Jackson, Jessica Luo, Rajen Somwaru, Alex A. Sons, Andrew Bean, Ronald N. Buckle, R. Jason Herr
Summary: We present a versatile method for the synthesis of N-substituted 3,4-dihydroisoquinolin-1(2H)-one compounds through a three-step sequence of cross-coupling, cyclization, N-deprotection, and N-alkylation. Mechanistic studies were conducted to understand the order of transformations in the cyclization and N-alkylation processes. This method was also applied to the synthesis of N-benzyl isoindolin-1-one and N-benzyl 2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Apurba Dutta, Diganta Sarma
Summary: A metal, solvent and oxidant free method has been developed for the synthesis of quinazolin-4(3H)-ones under microwave irradiation. Using the same catalyst, 2,3-dihydroquinazolin-4(1H)-ones were also synthesized in water as a green and sustainable solvent. These protocols offer a simplistic and rapid approach for assembling diverse structural quinazolinones.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Chemistry, Organic
Shiying Du, Zuguang Yang, Jianhua Tang, Zhengkai Chen, Xiao-Feng Wu
Summary: A nickel-promoted cascade annulation reaction has been developed for the synthesis of 3H-1,2,4-triazol-3-ones from easily available hydrazonoyl chlorides and sodium cyanate. The method involves a cascade of nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence, and has been successfully applied for the construction of the core skeleton of angiotensin II antagonist.
Article
Chemistry, Organic
Jin Luo, Juelin Wan, Lianlian Wu, Lingyun Yang, Tao Wang
Summary: This study describes an efficient and facile approach for the synthesis of quinazolin-4(3H)-ones via the reaction of quinazoline-3-oxides with primary amines. The method is applicable for a broad range of substrates and can proceed efficiently under metal-free and mild reaction conditions using easily available tert-butyl hydroperoxide as the oxidant. Remarkably, 3-(2-(1H-indol-3-yl)ethyl)quinazolin-4(3H)-one 3w, obtained in 70% yield through this process, serves as an excellent precursor for the synthesis of bioactive evodiamine and rutaempine.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Baihui Liang, Xiangya Cai, Jingyu Liu, Jie Huang, Youzhi Chen, Haiyin Deng, Quanquan Zhou, Tianxiang Chen, Xiuwen Chen, Zhongzhi Zhu
Summary: This study presents an efficient strategy for constructing 3H-1,2,4-triazol-3-ones via a copper-promoted [3 + 2] annulation reaction, which offers advantages such as cheap raw materials, high atom economy, and easy operation.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Helen A. Goulart, Jose S. S. Neto, Angelita M. Barcellos, Krigor B. Silva, Maiara C. de Moraes, Raquel G. Jacob, Eder J. Lenardao, Thiago Barcellos, Gelson Perin
Summary: A new method for the synthesis of 4-chalcogenyl-1H-isochromen-1-ones was developed using ultrasound irradiation, achieving high yields of the target compounds in a short period of time.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mehri Moeini Korbekandi, Iraj Mohammadpoor-Baltork, Majid Moghadam, Shahram Tangestaninejad, Valiollah Mirkhani, Akbar Omidvar, Behrouz Notash
Summary: This study focuses on the synthesis and characterization of a new catalyst, [HDPH]Cl-CuCl, made from diphenhydramine hydrochloride and CuCl. Various techniques were used to thoroughly characterize the prepared catalyst, and the observed hydrogen bond between the components was experimentally proven. The catalyst showed high effectiveness in the preparation of tetrahydrocinnolin-5(1H)-one derivatives and exhibited notable features such as one-pot operation, mild conditions, rapid reaction, high atom economy, and recyclability.
Article
Chemistry, Multidisciplinary
Ziqi Su, Hongxin Chai, Juan Xu, Jiarong Li
Summary: This method utilizes ZnCl2 to promote the synthesis of 1,3-benzoxazin-4-ones from 2-hydroxybenzonitriles and ketones, providing a high yield of substituted 1,3-benzoxazin-4-ones. It offers easy access to starting materials and eliminates the need for strong corrosive acids.
Article
Chemistry, Organic
Shalini Verma, Manoj Kumar, Akhilesh K. Verma
Article
Materials Science, Ceramics
M. Kumar, Mohinder Singh Chauhan, M. Shaheer Akhtar, Ahmad Umar
Summary: Nanostructured ZnO doped with different Ce precursor concentrations were prepared and tested for photocatalytic and chemical sensing performances. Blue-shift was detected in 5 mol% Ce doping, which was found to be the optimum concentration for achieving the maximum dye degradation and sensing performances. Facile redox couple Ce3+/Ce4+ improved charge separation, leading to increased catalytic and PA sensing performances.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Organic
Anuj Kumar, Manoj Kumar, Akhilesh K. Verma
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Apoorva Mittal, Manoj Kumar, N. Gopishankar, Pratik Kumar, Akhilesh K. Verma
Summary: This paper presents the development of a diacetylene-based dosimeter for determining therapeutic NB UVB doses during phototherapy. The synthesized diacetylene film, particularly the naphthylamine substituted one, showed excellent color transition under specific radiation doses. The developed dosimeter films can be easily applied to multiple sites on a patient's skin for simultaneous monitoring of doses during phototherapy at different anatomical regions, showing promising applications in routine clinical dosimetry.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Ceramics
Manoj Kumar, Ganesh Singh, M. S. Chauhan
Summary: Single-phase wurtzite hexagonal ZnO:Eu3+ nanoparticles were successfully synthesized through a facile co-precipitation method, with 5% doping exhibiting the highest catalytic efficiency. The samples showed improved photocatalytic performance for dye degradation under UV illumination compared to pure ZnO, and also exhibited weak ferromagnetic behavior.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Vishnu Kumar Modanawal, Sikandar Paswan, Afreen Anjum, Manoj Kumar, Shekhar Srivastava, Nitesh Jaiswal
Summary: Schiff base DBAP reacted with diethylenetriamine/ethylenediamine and cobalt(II)/copper(II) ions to form mixed ligand complexes, which were characterized by various spectroscopic techniques and studied for their nonlinear optical properties using DFT. The complexes showed good antibacterial activity against V. cholerae and E. coli in vitro.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Organic
Manoj Kumar, Aakanksha Gurawa, Nitin Kumar, Sudhir Kashyap
Summary: A direct and highly stereoselective glycosylation reaction catalyzed by Bi(OTf)(3) has been reported. The chemoselectivity of deactivated glycal donors can be controlled by tuning the solvent, leading to improved substrate scope. The versatility of this method has been demonstrated in the synthesis of oligosaccharides, as well as the 2-deoxyglycosylation of high-value natural products and drugs.
Article
Chemistry, Multidisciplinary
Aakanksha Gurawa, Manoj Kumar, Sudhir Kashyap
Summary: The study reports a new photolytic radical-induced vicinal azidooxygenation reaction method, which can efficiently convert various functionalized substrates, including unactivated alkenes, and form high-value drug analogs and bioactive skeletons in late-stage transformations.
Article
Chemistry, Organic
Manoj Kumar, Shalini Verma, Vivek Mishra, Oliver Reiser, Akhilesh K. Verma
Summary: The copper-catalyzed reactions under visible light irradiation have been successfully applied in the synthesis of aminated cyclopentene and cyclopentane derivatives. The method is compatible with various functionalities and demonstrates simplicity and affordability.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Physics, Multidisciplinary
Manoj Kumar, Narayan Behera, R. K. Singh, H. C. Joshi
Summary: Optical-time-of-flight and time-resolved spectroscopy were used to study the multiple velocity components and spectral behavior of laser-produced barium plasma in the presence of ambient gas and magnetic field. The structured temporal profiles of ionic and neutral species were more pronounced with the presence of ambient gas, magnetic field, or both. Different velocity components were analyzed using Multi-Shifted Maxwell-Boltzmann distribution functions, and their behavior varied with ambient gas and magnetic field. The observed results were explained based on the expansion of the plasma plume under different ambient conditions and the possible role of excitation and ionization processes.
Article
Chemistry, Multidisciplinary
Manoj Kumar, Nitin Kumar, Aakanksha Gurawa, Sudhir Kashyap
Summary: An alternative and highly efficient method for L-rhamnosylation using ruthenium reagent as a dual catalyst has been developed. This method allows the synthesis of biologically active α-L-rhamnopyranosides in good yields and can tolerate diverse functional groups.
Article
Chemistry, Multidisciplinary
Aakanksha Gurawa, Manoj Kumar, Sudhir Kashyap
Summary: The developed protocol allows for selective deprotection of acetyl groups in a wide range of substrates, including carbohydrates, amino acids, natural products, heterocycles, and general scaffolds. The environmentally friendly reagent system used in this method enables clean transformations under ambient conditions.
Article
Chemistry, Multidisciplinary
Manoj Kumar, Kuldeep Negi, Ahmad Umar, M. S. Chauhan
Summary: In this study, ZnO nanoparticles doped with various concentrations of lanthanum were successfully synthesized and characterized. Among them, the 1 mol% lanthanum-doped ZnO nanoparticles showed the highest efficiency in catalytic degradation of organic dyes and in fluorescent detection of picric acid.
Article
Chemistry, Multidisciplinary
Aakanksha Gurawa, Manoj Kumar, Dodla S. Rao, Sudhir Kashyap
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Organic
Manoj Kumar, Thurpu Raghavender Reddy, Aakanksha Gurawa, Sudhir Kashyap
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Organic
Geeta Devi Yadav, Pooja Chaudhary, Balaram Pani, Surendra Singh
Summary: Chiral transition metal complexes with privileged ligands are efficient catalysts for various asymmetric organic transformations. Transition metal complexes of C1-symmetric pyrrolidine-based ligands have been widely used in asymmetric organic reactions. However, a comprehensive review article on the transition metal complexes of chiral C1-symmetric pyrrolidine-based ligands derived from (L)-proline has not been published.
TETRAHEDRON LETTERS
(2024)
